Effects of Cissus populnea and Panax ginseng on Flutamide-Induced Testicular Defect in Pre-Pubertal Male Rats
A. A. Oremosu, V. O. Arowosaye, E. N. Akang, R. B. Bassey
Journal of Advances in Medicine and Medical Research · pp. 173–181 · Published 28 Dec 2012
10.9734/BJMMR/2013/1701Abstract
Aim: This study was carried out to determine the effects of Cissus populnea and Panax ginseng on flutamide-induced testicular toxicities in pre-pubertal rats. Place and Duration of Study: Department of Anatomy, College of Medicine of the University of Lagos, Lagos – Nigeria, between May and December 2010. Methodology: 20 male immature (25 days old) Wistar rats were used. They were randomly divided into 4 groups; 1 control and 3 treatment groups. Group A served as control, group B was administered flutamide and Cissus populnea, group C was administered flutamide and Panax ginseng and group D was administered flutamide alone. Body weight and testicular weights were measured. Hormonal assay for testosterone, FSH and LH were done using Enzyme-Linked Immunosorbent Assay (ELISA). Histopathology of the testis was also investigated. Result: There were no statistically significant differences in serum testosterone levels in all three treatment groups when compared with the control group. There was a significant increase in the serum LH level in group D when compared with the control group (p<0.05). Serum FSH level in group B showed a significant increase when compared with the control group (p<0.05). The histological evidences of testis in group D showed a reduction in lining cells of the seminiferous tubules; however, in the other three treatment groups they were similar to the control group. Conclusion: The results suggest that Cissus populnea and Panax ginseng ameliorates the adverse effects of flutamide on the testis.
Cited by 8
NtoJ Nto, Seno Akpobasaha, JosephO Ezugworie · International Journal of Medicine and Health Development · 2020
Eric Agbodjento, Jean Robert Klotoé, Téniola Isabelle Sacramento · Advances in Traditional Medicine · 2020
Omayma M. Mahmoud, Manal H. Al Badawi, Noha A. Salem · The Egyptian Journal of Histology · 2014
Layla A. S. Laylani · Al-Mustansiriyah Journal of Science · 2017
Damilare Emmanuel Rotimi, Ikponmwosa Owen Evbuomwan, Matthew Eboseremen Iyobhebhe · Biocatalysis and Agricultural Biotechnology · 2023
Wasiu Eniola Olooto, Adeniyi Olugbenga Fajobi, Omolara Oluwawemimo Adewole · African Journal of Urology · 2022
Abdulkareem Temitayo Olayinka, Airat Adeola Bakare, Ademola Ayodele Oremosu · Nigerian Journal of Experimental and Clinical Biosciences · 2022
K. Shai, S. L. Lebelo, J. W. Ng'ambi · All Life · 2022
Related research
- Could Co-Administration of Panax Ginseng and Vitamin E be More Effective in Reversing Nicotine- and Chronic Stress-induced Reproductive Toxicity in Male Albino Wistar Rats? — shares topic coverage
- The Cellular Toxicity of Panax ginseng Plant Extract against Certain Pathogenic Fungi and Human Lymphocytes — shares topic coverage
- Medicinal Plants in Physical Exercise: A Review — shares topic coverage
- Extraction and Testing of Natural Dye from Dafara (Cissus populnea) Stem Bark and Its Application on Cotton Fabric — shares topic coverage
- Extraction and Evaluation of a Saponin-base Surfactant from Cissus populnea Plant as an Emulsifying Agent — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
8
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.