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Synthesis of Some Novel Bis 1,3,4-Oxadiazole Fused Azo Dye Derivatives as Potent Antimicrobial Agents

A. H. Shridhar, J. Keshavayya, H. Joy Hoskeri, R. A. Shoukat Ali

International Research Journal of Pure and Applied Chemistry · pp. 119–129 · Published 23 Sep 2011

10.9734/IRJPAC/2011/493

Abstract

3,5-bis(5-(furan-2-yl)-1,3,4-oxadiazol-2-yl)azo dyes were synthesized by multistep reaction sequences, which is diazotized and coupled with different napthols and quinoline. Structure of newly synthesized compounds were characterized and confirmed by IR, NMR and Mass spectral studies. The newly synthesized azo dye fused with (5-(furan-2-yl)-1,3,4-oxadiazole) were screened for their acute toxicity and gross behavioral studies and in-vitro anti-microbial activity. Synthesized compounds exhibit significant biological activity and can certainly hold greater promise in discovering safer biologically active molecules.  

3,5-bis(5-(furan-2-yl)-1,3,4-oxadiazol-2-yl) azo dyes Anti-microbial activity Acute toxicity and gross behavioral studies

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