Preparation and Biomineralization of Injectable Hydrogel Composite Based Chitosan-tetronic  and BCP Nanoparticles

Thi Phuong Nguyen; Ngoc Quyen Tran

doi:10.9734/AIR/2016/25891

Research Article Open access CC BY 4.0

Preparation and Biomineralization of Injectable Hydrogel Composite Based Chitosan-tetronic and BCP Nanoparticles

Thi Phuong Nguyen, Ngoc Quyen Tran

Advances in Research · pp. 1–8 · Published 26 Apr 2016

10.9734/AIR/2016/25891

Abstract

In this study, a hydrogel composite was enzymatically prepared with rapid gelation time from tyramine-tetronic-conjugated chitosan and biphasic calcium phosphate (BCP) nanoparticles. Compressive stress of the hydrogel composite was reached at 591±20 KPa with 10 wt% of loaded BCP. Degradation study of the material showed 20% of weight loss after 4 weeks. In vitro study with MG 63 osteoblast cell evidenced that the cells were well-attached on hydrogel composite surfaces. Biomineralization on the hydrogel composites surfaces was well-observed after soaking for 14 days in simulated body fluid (SBF) solution. The obtained results indicated that the hydrogel composite could be an injectable potential material for bone regeneration.

Biomineralization injectable hydrogel composite BCP nanoparticles bone regeneration

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Thi Phuong Nguyen, Ngoc Quyen Tran (2016). Preparation and Biomineralization of Injectable Hydrogel Composite Based Chitosan-tetronic and BCP Nanoparticles. Advances in Research , 1–8. https://doi.org/10.9734/AIR/2016/25891

Affiliations

Thi Phuong Nguyen — Institute of Applied Materials Science, Vietnam Academy Science and Technology, Ho Chi Minh City 700000, Vietnam
Ngoc Quyen Tran — Institute of Applied Materials Science, Vietnam Academy Science and Technology, Ho Chi Minh City 700000, Vietnam

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