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Research Article Open access CC BY 4.0

Patient Characteristics and Outcome of Multi-organ Involvement in Dengue with Reference to SOFA Score

Sonali Salvi, Arun Vaidya

Asian Journal of Research in Infectious Diseases · pp. 47–54 · Published 26 Sep 2022

10.9734/ajrid/2022/v11i2216

Abstract

Background: Mortality in severe Dengue infection is attributed to development of MODS. Clinical profile, outcome and utility of SOFA score in Dengue MODS is not well studied in Indian context. Hence, this study was conducted to describe the “patient`s” characteristics and outcome in Dengue MODS with reference to SOFA score. Methods: We conducted an observational cross –sectional study in medicine department, Sassoon General Hospital Pune between January 2016 to January 2020. Adult dengue patients with multiorgan dysfunction based on SOFA score were included. Demographic, clinical and laboratory data were collected and analyzed. SOFA score was calculated at admission and monitor throughout admission course. Results: Total 69 patients were included. Male were 53.6% and mean age was 38.7±18.7 years. Most common symptoms were fever (98.6%), body ache & joint pain (69.6%), generalized weakness (62.3%), breathlessness (59.4%), headache (58%), anorexia (58%), abdominal pain & vomiting (55.1%) and bleeding manifestations (47.8%). Total 28% patients had two, 33% had three, 24.6% had four and 14.4% had ≥ 5 organs involvement. Maximum number of patients had hematological involvement (95.7%) followed by respiratory system involvement (63.8%). Mean duration of hospital stay was 9.8 days. Mortality was 43.5%. There was significant correlation of number of organs involved, pulse rate, respiratory rate, serum albumin, nervous system, respiratory system, SOFA score at admission and delta SOFA score with outcome. Conclusion: Dengue MODS has high mortality. Tachypnoea, tachycardia, hypoalbuminemia, respiratory failure and nervous system involvement are predictors of poor outcome. SOFA score at admission and its monitoring can serve as a useful marker to predict prognosis in dengue with multiple organ involvement.

Dengue MODS SOFA score outcome hypoalbuminemia

References (15)

  1. 1 The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure [DOI]
  2. 2 The global distribution and burden of dengue [DOI]
  3. 3 The global burden of dengue: an analysis from the Global Burden of Disease Study 2013 [DOI]
  4. 4 Evaluation of SOFA-based models for predicting mortality in the ICU: A systematic review [DOI]
  5. 5 Liver Biochemical Tests and Dengue Fever [DOI]
  6. 6 Dengue and Dengue Haemorrhagic Fever [DOI]
  7. 7 The outcomes of patients with severe dengue admitted to intensive care units [DOI]
  8. 8 AGA Technical review on the evaluation of liver chemistry tests [DOI]
  9. 9 A study of hepatic dysfunction in dengue.
  10. 10 Comparison of Apache II, SOFA, and Modified SOFA Scores in Predicting Mortality of Surgical Patients in Intensive Care Unit at Dr. Hasan Sadikin General Hospital
  11. 11 Initial Sequential Organ Failure Assessment score versus Simplified Acute Physiology score to analyze multiple organ dysfunction in infectious diseases in Intensive Care Unit [DOI]
  12. 12 Dengue infection with multiorgan dysfunction:-sofa score, arterial lactate and serum albumin levels are predictors of outcome [DOI]
  13. 13 A Study of Clinical Profile of Patients presenting with Complications of Acute Febrile Illnesses During Monsoon.
  14. 14 Dengue: multicentre clinical profile of patients admitted in intensive care unit [DOI]
  15. 15 Causes of Rural Urban Migration in India: Challenges and Policy Issues

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