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Research Article Open access CC BY 4.0

Platelet Rich Fibrin and Nanocrystalline Hydroxyapatite with Collagen Combination in Treatment of Periapical Lesion: A Novel Clinical Approach

Hena Rahman, Anil chandra, Abdul Aziz, Ramesh Bharti

Journal of Advances in Medicine and Medical Research · pp. 275–282 · Published 9 Sep 2014

10.9734/BJMMR/2015/12648

Abstract

Aims: To use platelet rich fibrin (PRF), which is an autologous platelet concentrate, along with nanocrystalline hydroxyapatite with collagen for treatment of periapical lesion and negotiation of calcified canal of adjacent tooth. Case Presentation: A 19-year-old female reported to the Department of Conservative Dentistry and Endodontics with chief complaint of pain in maxillary right central incisor. Past dental history revealed trauma which she sustained 10 yrs back in the same region. On intraoral examination, there was a draining sinus, in relation to the apex of 11. Also discolouration and crown fracture was found in relation to 11. Periapical radiograph revealed a large diffused periapical radiolucency in relation to 11 and 12, open apex of 11 and calcified root canal in relation to 12. Technique Used in the Study: A periapical surgery under local anaesthesia was planned in the region of maxillary right anterior region in relation to tooth no 11 and 12. Before surgery calcified canal of tooth no 12 was negotiated. PRF and nanocrystalline hydroxyapatite with collagen combination were placed in bony cavity. Follow up of the case was done for period of 6 months. Discussion: In present case combination of nanocrystalline hydroxyapatite with collagen and PRF is used, as it helps in faster bone regeneration. Graft material is osteoconductive and collagen network provides a better scaffold for clot formation and bone regeneration. Conclusion: The combination of PRF and nanocrystalline hydroxyapatite with collagen has been demonstrated to be an effective approach to induce faster periapical healing in present case with large periapical lesion.

PRF nanocrystalline hydroxyapatite pulp canal calcifications; apical periodontitis.

References (14)

  1. 1 Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor [DOI]
  2. 2 Regulation of Fibroplasia in Cutaneous Wound Repair [DOI]
  3. 3 Periodontal and Endodontic Regeneration [DOI]
  4. 4 Comparative Evaluation of Platelet-rich Plasma and Guided Tissue Regeneration Membrane in the Healing of Apicomarginal Defects: A Clinical Study [DOI]
  5. 5 Oral surgery—oral pathology conference no. 17, Walter Reed Army Medical Center [DOI]
  6. 6 Guided Tissue Regeneration in Periapical Surgery [DOI]
  7. 7 Effect of platelet‐rich plasma on the healing of intra‐bony defects treated with a natural bone mineral and a collagen membrane [DOI]
  8. 8 Treatment of Periodontal Intrabony Defects With Demineralized Freeze‐Dried Bone Allograft in Combination With Platelet‐Rich Plasma: A Comparative Clinical Trial [DOI]
  9. 9 Efficacy of Xenogeneic Bone Grafting With Guided Tissue Regeneration in the Management of Bone Defects After Surgical Endodontics [DOI]
  10. 10 Histology of Periapical Lesions Obtained During Apical Surgery [DOI]
  11. 11 Effect of Platelet‐Rich Plasma on the Healing of Intrabony Defects Treated With an Anorganic Bovine Bone Mineral and Expanded Polytetrafluoroethylene Membranes [DOI]
  12. 12 Clinical Effectiveness of Autologous Platelet‐Rich Plasma and Peptide‐Enhanced Bone Graft in the Treatment of Intrabony Defects [DOI]
  13. 13 Treatment of a large periapical lesion with loss of labial cortical plate using GTR: a case report.
  14. 14 Correction of a large periradicular lesion and mucosal defect using combined endodontic and periodontal therapy: a case report.

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