Evaluating Serum Urea, Creatinine and Hemoglobin Level in Chronic Renal Failure of Pre and Post Dialysis at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia

Abstract

Objective: The objective of this study was to evaluate serum urea, creatinine and hemoglobin level in chronic renal failure pre and post dialysis at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia. Methodology: Cross sectional study design was conducted From February to May 2017 to all chronic kidney failure patients Ethio-Egyptian Nephrology unit in SPHMMC Addis Ababa Ethiopia. 5 ml of the blood was obtained from each patient before and after dialysis. Each sample was divided in to two; half of the blood was placed in tubes containing anticoagulant (EDTA) and half in clot activator tubes. Clotted blood was centrifuge to separate serum and used for the estimation of creatinine and urea. Non-clotted blood samples were used for complete blood count and hemoglobin in blood Analyzer Sysmax KX-21. Percentages of reduction in urea and creatinine values were calculated using the values of blood samples withdrawn from each patient before and after each hemodialysis sessions. Results: A total of 33 chronic kidney patients participated in this study. Out of this only 26 patients (78.79%) attend the dialysis unit for four months the rest either passed away or kidney transplantation done. The study population comprised 80.8% male and 19.2% female. Before the dialysis, 12 (46.2%) patients serum urea level was 101-122 mg/dl, however after dialysis, 14 (53.8%) patients had serum urea level were between 20 – 50.99 mg/dl and 11 (42.3%) patients had serum urea level were between 51 – 100 mg/dl. Most of the patients, (53.8%) undergoing hemodialysis serum creatinine level before dialysis were between 7.6 – 10.5 mg/dl. The majority of patients’ (42.3%), serum creatinine level after dialysis was between 3.0 – 3.92 mg/dl.  The majority (73.1%) of the patient hemoglobin level was between 7.0 – 11.0 mg/dl and 23.1% of the patients were between 11.1 – 14.0 mg/dl. Patients with chronic kidney disease have high serum urea and creatinine level before hemodialysis. Conclusion: Hemodialysis decreases the burden of kidney in chronic kidney disease patients.