Potential Protective Effects of Blackberry and Quercetin on Sodium Fluoride-inducedImpaired Hepato-renal Biomarkers, Sex Hormones and Hematotoxicity in Male Rats
Hayat A. A. Ismail, Reham Z. Hamza, Nahla S. El-Shenawy
Journal of Applied Life Sciences International · pp. 1–16 · Published 30 Jul 2014
10.9734/JALSI/2014/12057Abstract
Aim: The present study was carried out to evaluate the potential protective role of blackberry juice (BBJ) and quercetin (Q) against sodium fluoride-induced liver damage and impairment of kidney function, as well as hematotoxicity in rats. Study Design: After 2 weeks of acclimation, animals were divided into seven groups, ten rats each. All the groups were treated interaperitoneal (i.p.) for 30 successive days. Group 1 served as untreated control and received 1ml/Kg of distilled water i.p. daily. Group 2 was given i.p. BBJ at a dose of 1.6g/kgb.wt. containing 5mg anthocyanin. Group 3 was given quercetin at dose of 75mg/Kgb.wt. Group 4 was treated with 10.3mg/kg b.wt of NaF. Group 5 was given i.p. BBJ followed by NaF at the same doses. Group 6 was given quercetin followed by NaF and finally group 7 was treated with BBJ and Q then followed by NaF as mentioned previous doses. Methodology: Some hematological parameters were determined. Serum aspartate transaminase, alanine transaminase and alkaline phosphatase activities were as well as lipid profile and total protein were evaluated as biomarkers for liver functions. The levels of uric acid and creatinine in serum were estimated. Hormones of testosterone and inhibin B were assessed. Results: Sodium fluoride (NaF) caused an elevation in serum transaminases and alkaline phosphatase and reduced serum total protein, testosterone, and inhibin-B levels as well as levels of uric acid and creatinine, and induced hematotoxicity. It increased all the parameters of lipid profile except the high density lipoprotein cholesterol level was decreased. The presence of Q or BBJ with NaF successfully mitigated liver and kidney functions, which was more pronounced with Q. Conclusion: It can be concluded that concomitant administration of Q or BBJ with NaF may be useful in reversing the toxicity of NaF in male rats.
References (44)
- 1 Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge [DOI]
- 2 Health effects of quercetin: From antioxidant to nutraceutical [DOI]
- 3 Metabolomics: Current analytical platforms and methodologies [DOI]
- 4 Update on Uses and Properties of Citrus Flavonoids: New Findings in Anticancer, Cardiovascular, and Anti-inflammatory Activity [DOI]
- 5 Enzymatic determination of triglyceride, free cholesterol, and total cholesterol in tissue lipid extracts [DOI]
- 6 Chronic Fluoride Toxicity: Dental Fluorosis [DOI]
- 7 Atheroprotective Effects of High-Density Lipoproteins [DOI]
- 8 Potential protective effects of quercetin and curcumin on paracetamol-induced histological changes, oxidative stress, impaired liver and kidney functions and haematotoxicity in rat [DOI]
- 9 Influence of Cultivar, Maturity, and Sampling on Blackberry ( Rubus L. Hybrids) Anthocyanins, Polyphenolics, and Antioxidant Properties [DOI]
- 10 Antioxidative and Hepatoprotective Effects of Antrodia camphorata Extract [DOI]
- 11 Antitumor activities of quercetin and quercetin-5′,8-disulfonate in human colon and breast cancer cell lines [DOI]
- 12 Fluoride-induced histopathology and synthesis of stress protein in liver and kidney of mice [DOI]
- 13 Foodstuffs for Preventing Cancer: The Preclinical and Clinical Development of Berries [DOI]
- 14 Testicular toxicity in sodium fluoride treated rats: association with oxidative stress [DOI]
- 15 Protective effect of catechin and quercetin on chlorpyrifos-induced lung toxicity in male rats [DOI]
- 16 Evaluation of free radical-scavenging and anti-oxidant properties of black berry against fluoride toxicity in rats [DOI]
- 17 Quercetin ameliorates glucose and lipid metabolism and improves antioxidant status in postnatally monosodium glutamate-induced metabolic alterations [DOI]
- 18 RETRACTED: Epigallocatechin gallate supplementation protects against renal injury induced by fluoride intoxication in rats: Role of Nrf2/HO-1 signaling [DOI]
- 19 Blackberry Anthocyanins Are Slightly Bioavailable in Rats [DOI]
- 20 Fluoride-induced disruption of reproductive hormones in men [DOI]
- 21 The effect of naringin, a bioflavonoid on ischemia-reperfusion induced renal injury in rats [DOI]
- 22 The Determination of Bio-Available Testosterone [DOI]
- 23 Can Arabidopsis make complex alkaloids? [DOI]
- 24 Antioxidant Defense System and Lipid Peroxidation in Patients with Skeletal Fluorosis and in Fluoride-Intoxicated Rabbits [DOI]
- 25 Activation of phosphatidylinositol 3-kinase is required for tumor necrosis factor-α-induced upregulation of matrix metalloproteinase-9: Its direct inhibition by quercetin [DOI]
- 26 Evaluation of propolis effects on some biochemical parameters in rats treated with sodium fluoride [DOI]
- 27 OXIDATIVE STRESS FROM FLUORIDE-INDUCED HEPATOTOXICITY IN RATS
- 28 Fluoride‐induced changes in haem biosynthesis pathway, neurological variables and tissue histopathology of rats [DOI]
- 29 Effects of sodium fluoride exposure on some biochemical parameters in mice: Evaluation of the ameliorative effect of royal jelly applications on these parameters [DOI]
- 30 Protective effect of thymoquinone on sodium fluoride-induced hepatotoxicity and oxidative stress in rats [DOI]
- 31 Experimental studies on effect of sodium fluoride and nitrate on biochemical parameters in rats
- 32 Effects of selenium and zinc on renal oxidative stress and apoptosis induced by fluoride in rats.
- 33 Pharmacokinetics in the Oral Cavity: Fluoride and Other Active Ingredients [DOI]
- 34 Antihyperglycaemic effect of Casearia esculenta root extracts in streptozotocin-induced diabetic rats.
- 35 The Effect of Acute Fluoride Poisoning on Nitric Oxide and Methemoglobin Formation in the Guinea pig
- 36 The crystal structure of fluoride-inhibited cytochrome c peroxidase. [DOI]
- 37 Effect of fluoride on rat testicular steroidogenesis
- 38 Calcium channel blocking agents protect against acetaminophen‐induced cytotoxicity in rat hepatocytes [DOI]
- 39 Management of Cholestasis in Infants With Very Low Birth Weight [DOI]
- 40 Display of an inhibin epitope in a surface-exposed loop of the E. coli heat-labile enterotoxin B subunit [DOI]
- 41 Effects of sodium fluoride on total serum protein levels and transaminase activity in rats [DOI]
- 42 The Structural and Biochemical Changes of Kidney Tissue on Fluorosis in Rabbits
- 43 Selected Methods in Clinical Chemistry. [DOI]
- 44 Fluoridation of drinking water and chronic kidney disease: absence of evidence is not evidence of absence [DOI]
Cited by 18
Samy El-Megharbel, Eman Al-Thubaiti, Safa Qahl · Crystals · 2022
Wenchao Tang, Yuanyuan Xiao, Guannan Li · Ecotoxicology and Environmental Safety · 2018
Azab Elsayed Azab, Mohamed Omer Albasha, J. M. Jbireal · Open Journal of Apoptosis · 2018
Hanaa A. Hassan, Hanaa M. Serage, Wafaa Gad · Egyptian Journal of Basic and Applied Sciences · 2015
Reham Zakaria Hamza, Mohammad Salem Al-Harbi · Asian Pacific Journal of Tropical Disease · 2015
Sallam K. Tony, Mohamed SH. Hassan, Hamadi A. Ismail · Environmental Science and Pollution Research · 2023
Wenchao Tang, Xi Zheng, Dan Li · Environmental Toxicology and Pharmacology · 2018
Samy M. El-Megharbel, Fawziah A. Al-Salmi, Moamen S. Refat · Crystals · 2021
Showing 8 of 18 known citations — external sources report more than can currently be individually listed.
Related research
- Modulatory Roles of Clove and Fermented Ginger Supplements on Lipid Profile and Thyroid Functions in High Fat Diet Induced Insulin Resistance in Rabbits — shares topic coverage
- Influence of Vitamin D Level on Diabetic Dyslipidemia — shares topic coverage
- Lipid Profile in School Children Infected with Urinary Schistosomiasis in Fante Akura-Yeji, Ghana — shares topic coverage
- Pattern of Lipid Profile Levels in HIV Serodiscordant Couples in Jos Plataeu State, Nigeria — shares topic coverage
- Changes in Liver Histomorphology, Hematological Parameters and Lipid Profile of Cadmium-Exposed Rats Treated with Combined Leaf Extract of Vernonia amygdalina and Occimum gratissimum — shares topic coverage
Article metrics
Real usage data collected on this platform.
42
Page views
0
PDF downloads
35
Outbound clicks
18
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.