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Research Article Open access CC BY 4.0

Prescribing Pattern of Antimicrobials in Patients during Post-Operative Period – An Observational Study

R. Revathi, N. Sarala, A. Bhaskaran

Journal of Advances in Medicine and Medical Research · pp. 1213–1219 · Published 30 Oct 2014

10.9734/BJMMR/2015/11259

Abstract

Background: Understanding prescribing pattern of antimicrobials in postoperative period will provide data pertaining to efficacy of prophylaxis during post surgical period and economic burden faced by patients. This data will help local authorities formulate practical guidelines to ensure their rational prescription. Our aim was to evaluate the type and dosage schedule of antimicrobials used in post-operative patients and to estimate the cost of antimicrobials in these patients. Materials and Methods: This is a prospective observational study conducted by the Department of Pharmacology at R.L. Jalappa Hospital and Research Centre attached to Sri Devaraj Urs Medical College between April and September 2013. All patients above the age of 18 years undergoing surgical procedures in the departments of Orthopedics, Surgery and ENT and hospitalised were included. Results: There were 500 patients, 351 males and 149 females. The mean age and duration of stay was 43.15±16.8 years and 6.7±3.1 days respectively. Types of surgeries were, fracture fixation (31.8%), head and neck (18.2%), soft tissue - extremities (18.0%), abdominal (9.4%) and others (22.6%). All patients received antimicrobials prophylactically. 72% of the patients received anti-microbials for more than 24 hours. Commonly prescribed antimicrobials were cephalosporins (54.6%) and aminoglycosides (22.3%). The daily defined dose (DDD) /1000 patient days) was highest for aminoglycoside - amikacin (296.96±63.5). Conclusion: All patients received prophylactic antimicrobials and more than seventy percent were continued with the antimicrobials in the post operative period to prevent surgical site infection. However use of third generation cephalosporins was extensive, which may result in the development of resistance to these agents in the near future.

Antimicrobials post-operative patients daily defined dose

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Cited by 4

ANTIBIOTIC PROPHYLAXIS USE IN PATIENTS ADMITTED IN GENERAL SURGERY DEPARTMENT AT A TERTIARY CARE TEACHING HOSPITAL IN HARYANA

ARVIND NARWAT, MAMTA SHARMA, PREM PRAKASH KHOSLA · Asian Journal of Pharmaceutical and Clinical Research · 2023

Drug utilization pattern of antimicrobial agents in postoperative patients of major surgery in the general surgical wards at a tertiary care teaching hospital

Anushri P. Gaikwad, Rohidas M. Barve, Rohini Jagtap · International Journal of Research in Medical Sciences · 2025

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