Skip to content
Research Article Open access CC BY 4.0

Prescribing Pattern of Antimicrobials in Patients during Post-Operative Period – An Observational Study

R. Revathi, N. Sarala, A. Bhaskaran

Journal of Advances in Medicine and Medical Research · pp. 1213–1219 · Published 30 Oct 2014

10.9734/BJMMR/2015/11259

Abstract

Background: Understanding prescribing pattern of antimicrobials in postoperative period will provide data pertaining to efficacy of prophylaxis during post surgical period and economic burden faced by patients. This data will help local authorities formulate practical guidelines to ensure their rational prescription. Our aim was to evaluate the type and dosage schedule of antimicrobials used in post-operative patients and to estimate the cost of antimicrobials in these patients. Materials and Methods: This is a prospective observational study conducted by the Department of Pharmacology at R.L. Jalappa Hospital and Research Centre attached to Sri Devaraj Urs Medical College between April and September 2013. All patients above the age of 18 years undergoing surgical procedures in the departments of Orthopedics, Surgery and ENT and hospitalised were included. Results: There were 500 patients, 351 males and 149 females. The mean age and duration of stay was 43.15±16.8 years and 6.7±3.1 days respectively. Types of surgeries were, fracture fixation (31.8%), head and neck (18.2%), soft tissue - extremities (18.0%), abdominal (9.4%) and others (22.6%). All patients received antimicrobials prophylactically. 72% of the patients received anti-microbials for more than 24 hours. Commonly prescribed antimicrobials were cephalosporins (54.6%) and aminoglycosides (22.3%). The daily defined dose (DDD) /1000 patient days) was highest for aminoglycoside - amikacin (296.96±63.5). Conclusion: All patients received prophylactic antimicrobials and more than seventy percent were continued with the antimicrobials in the post operative period to prevent surgical site infection. However use of third generation cephalosporins was extensive, which may result in the development of resistance to these agents in the near future.

Antimicrobials post-operative patients daily defined dose

References (16)

  1. 1 Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America Guidelines for Developing an Institutional Program to Enhance Antimicrobial Stewardship [DOI]
  2. 2 Clinical practice guidelines for antimicrobial prophylaxis in surgery [DOI]
  3. 3 Burden of endemic health-care-associated infection in developing countries: systematic review and meta-analysis [DOI]
  4. 4 A Five-Year Prospective Study of 23,649 Surgical Wounds [DOI]
  5. 5 THE NATIONWIDE NOSOCOMIAL INFECTION RATE [DOI]
  6. 6 Multivariable Predictors of Postoperative Surgical Site Infection after General and Vascular Surgery: Results from the Patient Safety in Surgery Study [DOI]
  7. 7 Infection control as a major World Health Organization priority for developing countries [DOI]
  8. 8 The Effect of Increasing Age on the Risk of Surgical Site Infection [DOI]
  9. 9 Prevalence of nosocomial wound infection among postoperative patients and antibiotics patterns at teaching hospital in Sudan [DOI]
  10. 10 Appropriate use of antimicrobial agents: Challenges and strategies for improvement [DOI]
  11. 11 Factors Associated With Postoperative Infection [DOI]
  12. 12 Prescribing patterns of antibiotics and sensitivity patterns of common microorganisms in the Internal Medicine ward of a teaching hospital in Western Nepal: a prospective study [DOI]
  13. 13 Cephalosporins in Surgical Prophylaxis [DOI]
  14. 14 Audit of antibiotic use in a Brazilian University Hospital [DOI]
  15. 15 Focused microbiologic surveillance by specific hospital unit: practical application and clinical utility.
  16. 16 Principles and Practice of Infectious Diseases. [DOI]

Cited by 4

ANTIBIOTIC PROPHYLAXIS USE IN PATIENTS ADMITTED IN GENERAL SURGERY DEPARTMENT AT A TERTIARY CARE TEACHING HOSPITAL IN HARYANA

ARVIND NARWAT, MAMTA SHARMA, PREM PRAKASH KHOSLA · Asian Journal of Pharmaceutical and Clinical Research · 2023

Drug utilization pattern of antimicrobial agents in postoperative patients of major surgery in the general surgical wards at a tertiary care teaching hospital

Anushri P. Gaikwad, Rohidas M. Barve, Rohini Jagtap · International Journal of Research in Medical Sciences · 2025

Showing 2 of 4 known citations — external sources report more than can currently be individually listed.

Related research

Article metrics

Real usage data collected on this platform.

38

Page views

0

PDF downloads

8

Outbound clicks

4

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.