Prevalence of Hashimoto’s Thyroiditis and Its Association with Vitamin D Deficiency in West Bengal, India

Abstract

Objective: The aim of our study is to screen the prevalence of Hashimoto’s Thyroiditis and to evaluate a correlation between 25(OH)Vitamin D deficiency and AITD in hypothyroid patients of West Bengal. Study Design: Ethical clearance was received for the study. 130 patients from the Medicine OPD of Ramakrishna Mission Seva Pratishthan (RKMSP) and 100 healthy individuals were included in the study from March to July 2015. Methodology: Brief clinical history was taken from all the subjects and  serum 25(OH)Vitamin D, Thyroid Stimulating Hormone (TSH), Thyroid peroxidise antibody (TPOab), Parathyroid hormone (PTH)  were estimated by Cobas e 601 Immuno assay auto-analyzer. Results: 48.4% (63/130) of the screened patients were found to have AITD with elevated level of anti-TPO in their serum. The prevalence of vitamin D deficiency was significantly higher in patients with AITD compared to controls (Group I: 14.67±4.51; Group II: 11.26±2.8 vs Control: 28.66±8.3 respectively, p<0.0001). There was a significant inverse association between serum 25(OH)D and Hashimoto’s Thyroiditis established by the negative r values (Group I: r = -0.2 , p=0.03; Group II: r = -0.5, p=0.013 vs Control: r=0.07, p=0.48). Conclusion: It has been demonstrated from this study that all the patients with Hashimoto’s Thyroid disorder had significantly low serum 25(OH)vitamin D suggesting its involvement in the pathogenesis of AITD.