Nutrient and Anti-diabetic Activity of Azadirecta indica and Corriandrum sativum Leaf Extract on Allaxon Induced Diabetic Rat

Abstract

Azadirecta indica (Meliaceae) is a medicinal plant, commonly known as ‘Neem’ and distributed randomly in the whole of India. Corriandrum sativum belongs to the family of Apiaceae was considered to be native from Asia and Africa and known locally in Sudan as Kazbra. Azadirecta indica and Corriandrum sativum extract have been studied for therapeutic possessions. The nutrient parameters and gas chromatography mass spectroscopy (GC-MS) analysis in the leaves of Azadirecta indica and Corriandrum sativum were studied and also the antihyperglycemic activity of hydro alcoholic extract. An acute oral toxicity study was carried out in healthy male Wister rats (100 g). Diabetic rats were orally and daily administrated of hydro alcoholic leaf extract of A. indica and C. sativum at the different doses (200-400 mg/kg. b.w) with anti-diabetic reference drug (metformin). After 21st days of treatment, level of blood glucose, as well as Albumin, Protein, Creatinine, Urea and Uric acid were significantly decreased when compared with the diabetic control. These plant fruit extract will be subjected for further extensive studies to isolate and identify their active constituents which are useful for against antidiabetic. Ethanol leaf extract of Azadirecta indica effect was confirmed minerals such as sodium (Na), copper (Cu), magnesium (Mg), manganese (Mn), Cobalt (Co) and iorn (Fe) were decreases of the respect of Corriandrum sativum. The results was indicated that the hydro alcoholic extract from leaves of Azadirecta indica and Corriandrum sativum showed the reduced blood glucose and other biochemical parameters level were observed in diabetic rats treated with both doses of ethanol extract of Azadirecta indica and Corriandrum sativum leaf compared to diabetic control rats. These observed strongly suggest that hydro alcoholic extract could act as a source of functional compounds for the control of diabetes mellitus.