Human Homeobox Genes in Development and Cancer
International Research Journal of Oncology · pp. 248–260 · Published 8 Dec 2023
Abstract
The homeobox (HOX) genes encode highly conserved, homeodomain-containing transcriptional factors that play a central role in embryonic development and the maintenance of cellular identity crucial to the differentiation of adult stem cells. Implicitly, the pathophysiological relevance of these genes is life-long as evident in many developmental anomalies and adult disorders, particularly cancers. This review considers the normal pattern of HOX gene expression and the signalling pathways involved in its regulation, discusses the consequences of HOX gene dysregulation associated with dysmorphogenesis and carcinogenesis, and the plausibility of a common mechanism underlying both processes. Finally, it looks at the mechanisms that underlie potential interventions in cases where cancers are promoted by HOX gene dysregulation.
Cited by 0
No indexed citations yet.
Related research
- Epstein-Barr Virus; A Nascent Viral Link with Oral Squamous Cell Carcinoma — shares topic coverage
- Commensals and Foodborne Pathogens can Arbitrate Epithelial-carcinogenesis — shares topic coverage
- Comprehensive Roles of TP53 in Cell Signaling, Apoptosis and Carcinogenesis – A Review — shares topic coverage
- Effects of Injected N-methyl-N-nitrosourea (MNU) in Albino Mice on the Histology and Haematology of Selected Organs of the Circulatory, Lymphoid and Digestive Systems — shares topic coverage
- Assessment of Chemoprotective Potential of Curcumin against DMBA-Croton Oil Induced Skin Cancer in Mice — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
0
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.