Research Progress on the Role of Inflammation in Kawasaki Disease

Abstract

As the pathogenesis of Kawasaki disease continues to evolve, researchers have proposed a number of hypotheses, from viral infections, genetic and environmental influences, to toxin-mediated autoinflammatory responses.More and more attention has been paid to the role of inflammation in KD (Kawasaki disease) pathogenesis.Objective: To explore the role of inflammation in Kawasaki disease and to provide a new idea for the diagnosis and treatment of KD.Methods: A systematic search was conducted from PubMed and CNKI databases (last updated on March 31, 2023) for relevant and qualified articles evaluating the role of inflammation in KD. Results: The research results of the last five years were selected from these articles for meta-analysis.Conclusion: Through comprehensive analysis, we conclude that inflammatory response is the main process of vascular damage in Kawasaki disease, especially the NLRP3 inflammasome which plays an important role.However, the etiology and pathogenesis of KD are very complex, and inflammation is only one manifestation. More and more studies have shown that inflammation plays a crucial role in the pathogenesis of Kawasaki disease, which has been recognized,and we comprehensively describe some important roles and latest research perspectives of inflammation in Kawasaki disease.