Effects of the Ethanol Extract of the Stem Bark of Nauclea latifolia Smith [Rubiaceae] on Certain Biochemical and Haematological Indices of Swiss Albino Mice
Chinweizu Ejikeme Udobi, Betseabasi Edward Umoh, Ememobong Gideon Asuquo
Asian Journal of Medicine and Health · pp. 1–9 · Published 28 Jul 2017
10.9734/AJMAH/2017/33284Abstract
The ethanol extract of the stem bark of Nauclea latifolia was investigated for its effect on certain haematological and biochemical indices of the swiss albino mice. Phytochemical screening of the extract for bioactive compounds indicated the presence of saponins, tannins, terpenes, cardenolide, balsams, alkaloids, flavonoids and cardiac glycosides, phlobatanins, cyanogenic glycosides and anthraquinones. The LD50 was determined to be 1414.2 mg/kg body weight. Sub-acute and chronic administration of the extract caused a significant increase of some heamatological indices as the dose administered increased from low to high while WBC level was observed to decrease. Biochemical indices such as globulin, urea and AST levels increased significantly as the dose administered increased from low to high, while albumin, total protein, ALT and ALP levels were observed to decrease. Results obtained also suggests certain effects on the heart and kidney with prolonged use. Nuclea latifolia stem bark extract should be used with caution.
Cited by 6
M. C. Udeh Sylvester, V. N. Ogugua, E. Y. Ojochenemi · Pharmacologia · 2023
Ezekiel Iliya, Igimi O Agnes, S. O. Ajayi · Dutse Journal of Pure and Applied Sciences · 2022
Lucky Legbosi Nwidu, Y. Oboma · GSC Biological and Pharmaceutical Sciences · 2019
O. Ogunrinola, O. Fajana, S. Olaitan · JOURNAL OF RESEARCH AND REVIEW IN SCIENCE · 2018
L. L. Nwidu, Y. Oboma · 2019
Udeh Sylvester Michael Chukwuka, Ogugua Vincent Nwadiogbu, Ojochenemi Ejeh Yakubu · International Journal of Biological Chemistry · 2023
Related research
- Effects of Hydro-ethanolic Leaf Extract of Tithonia diversifolia on Parasitaemia Level, Serum Metabolites and Histopathology of Organs in Swiss Albino Mice Infected with Plasmodium berghei NK65 — shares topic coverage
- Idiopathic Bilateral Wunderlich Syndrome: A Case Report — shares topic coverage
- Therapeutic Potential of Ginger-supplemented Diet in Reversing Lead-induced Nephrotoxicity — shares topic coverage
- Immunohistochemical Effects of Lutein on Paraquat-induced Toxicity in Kidneys and Liver of Adult Wistar Rats — shares topic coverage
- Effects of Tobacco Cigarette Smoking on Some Hematological Parameters of Male Cigarette Smokers in Southern Nigeria — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
6
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.