Cisplatin Induced Nephrotoxicity- An Assessment Based on Calculated Creatinine Clearance

Abstract

Background: Cancer is a group of more than 100 different diseases that are characterized by uncontrolled cellular growth, local tissue invasion, and distant metastases. Cisplatin is the most widely used anti-neoplastic agent for most of the tumors like lung cancer, gastric cancers, ovarian cancer, penile cancer, cervical cancer and many other. Nephrotoxicity is the main side effect of cisplatin. Aim: To determine the incidence and evaluate the risk factors of cisplatin induced nephrotoxicity. Methods: A prospective-observational study was conducted in the Department of Radio Therapy in a tertiary care hospital for 6 months from February 2015 to July 2015. Results: Incidence of nephrotoxicity was high in male patients in other studies. But in our study more female patients are affected with nephrotoxicity, it may be due to inclusion of pelvic Malignancy cases in our study. Few patients also had co-morbid conditions like hypertension and diabetes mellitus. Conclusion: Female sex was a risk factor for cisplatin induced nephrotoxicity although the cancer type may also contribute to increase in nephrotoxicity.