Reduction of Plasma Adiponectin in Egyptian Obese Children with Nonalcoholic Fatty Liver Disease
Amal Ahmed Mohamed, Maha Abd El Ghany, Hassan Shalaby, Dalal M. El-Melligy, Khadega K. El Gohary, Ayman Mohamed Abdel Aziz, Dalia A. El-Damasy
International Journal of Biochemistry Research & Review · pp. 225–232 · Published 17 Dec 2014
10.9734/IJBCRR/2015/13737Abstract
Reduction of Plasma Adiponectin in Egyptian Obese Children with Nonalcoholic Fatty Liver Disease Background: Obesity, insulin resistance and dyslipidemia are the most significant risk factors of non-alcoholic fatty liver disease (NAFLD) in children, and a major cause of liver-related morbidity. The aim of this study was to evaluate the serum levels of adiponectin, leptin and fasting insulin in obese children with NAFLD to explore the role of adiponectin in the pathogenesis of this disease. Materials and Methods: The fasting serum levels of adiponectin, leptin, glucose, insulin, ALT, AST, total bilirubin, direct bilirubin, albumin, alkaline phosphatase, creatinine, cholesterol, triglycerides, HDL, LDL, GGT and CRP were measured in a group of 50 NAFLD children after making ultrasonography and 40 other participants were considered as a control group with comparable age, sex and body-mass index. Results: Plasma adiponectin was found significantly low in NAFLD children than its level in control group (3.23 2.5 vs 11.0 2.95 ng/dl). Moreover, NAFLD group had significantly higher insulin resistance, fasting insulin 11.4 4.9 vs 4.73.1 mu/l levels in comparison with control group. Regarding serum leptin, there was no significant difference. An inverse correlation was observed between adiponectin and homeostatic model assessment (HOMA-IR), fasting insulin, leptin, triglycerides, ALT, AST, GGT and BMI. Conclusion: This data supports a role for low circulating adiponectin value in the pathogenesis of NAFLD and its association with insulin resistance.
References (24)
- 1 Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man [DOI]
- 2 Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity [DOI]
- 3 AGA technical review on nonalcoholic fatty liver disease [DOI]
- 4 Heritability of Nonalcoholic Fatty Liver Disease [DOI]
- 5 Cardiovascular Risk Factors and the Metabolic Syndrome in Pediatric Nonalcoholic Fatty Liver Disease [DOI]
- 6 Alanine Aminotransferase Levels and Fatty Liver in Childhood Obesity: Associations with Insulin Resistance, Adiponectin, and Visceral Fat [DOI]
- 7 Adipokines in NASH: Postprandial Lipid Metabolism as a Link Between Adiponectin and Liver Disease * [DOI]
- 8 Serum Leptin Levels in Patients With Nonalcoholic Steatohepatitis [DOI]
- 9 Pediatric Nonalcoholic Fatty Liver Disease [DOI]
- 10 Pediatric non-alcoholic fatty liver disease: an increasing public health issue [DOI]
- 11 Review article: epidemiology, pathogenesis and potential treatments of paediatric non‐alcoholic fatty liver disease [DOI]
- 12 Pediatric Nonalcoholic Fatty Liver Disease in 2009 [DOI]
- 13 Serum Adiponectin, Resistin Levels and Non-alcoholic Fatty Liver Disease in Obese Children [DOI]
- 14 Adiponectin, hepatocellular dysfunction and insulin sensitivity [DOI]
- 15 Decreased Serum Adiponectin: An Early Event in Pediatric Nonalcoholic Fatty Liver Disease [DOI]
- 16 Unravelling the pathogenesis of fatty liver disease: patatin-like phospholipase domain-containing 3 protein [DOI]
- 17 Relation of Leptin to Insulin Resistance Syndrome in Children [DOI]
- 18 Nonalcoholic fatty liver disease: a challenge for pediatricians [DOI]
- 19 Metabolic, Hormonal, Oxidative, and Inflammatory Factors in Pediatric Obesity-related Liver Disease [DOI]
- 20 Ethnicity, obesity and the metabolic syndrome: implications on assessing risk and targeting intervention [DOI]
- 21 The association between non‐alcoholic fatty liver disease and insulin resistance in 20 obese children and adolescents [DOI]
- 22 Serum concentration of adiponectin, leptin and resistin in obese children with non-alcoholic fatty liver disease [DOI]
- 23 Fatty liver in childhood [DOI]
- 24 Serum leptin levels in patients with nonalcoholic chronic liver disease.
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