Tranexamic Acid as Prophylactic Therapy for Intra and Post Partum Hemorrhage, Randomized Controlled Trial

Abstract

Objective: To evaluate the role of TXA in minimizing the incidence of postpartum hemorrhage after cesarean delivery. Methodology: This is a randomized placebo controlled study conducted on 169 patients who subjected to elective CS. Study group include 84 patients who received 2 gm Tranexamic acid before induction of anaesthesia plus 10 u oxytocin. The control group received only 10 U oxytocin. Both group were compared as regard amount of blood loss. Results: The amount of blood loss was lower in study group than control group (410.33±175.08 ml versus 650.25±180.90 ml). Also the 24 hours post-operative hemoglobin was significantly higher in study group (10.68±0.9 mg/dl) compared to control group (8.2±0.7 mg/dl), as well as, the 24 hours post-operative hematocrit value was significantly higher in study group (37.63±5.4) compared to control (31.19±2.48). Conclusion: Tranexamic acid could be helpful option in reducing amount of blood loss during elective CS.