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Research Article Open access CC BY 4.0

Role of Different Ovulation Induction Protocols in Follicular Growth, Estradiol and Pregnancy Rates for Women with Unexplained Infertility and Polycystic Ovary Syndrome Undergoing Intrauterine Insemination

Muhammad-Baqir M-R. Fakhrildin, Sundus Fadhil Hantoosh, Rajwa Hasen Essa, Manal Taha Meteab

Journal of Advances in Medicine and Medical Research · pp. 1–10 · Published 14 Mar 2017

10.9734/BJMMR/2017/31988

Abstract

Introduction: The study aimed to study the effects of ovulation induction programs on the number of pre-ovulatory dominant follicles and endometrial thickness, their effects on pre-ovulatory estradiol 2 levels, and to determine the favored ovulation induction protocol to attain better pregnancy results in polycystic ovary syndrome and unexplained infertility women. Materials and Methods: Twenty unexplained infertile and thirty polycystic ovary syndrome women subjected to ovulation induction/intrauterine insemination were enrolled in this study. First ovulation induction protocol involved clomiphene citrate only, the second involved Gonal-f only, and the third involved combination of clomiphene citrate and Gonal-f. Immediately before triggering of ovulation, follicular parameters, endometrial thickness, and estradiol 2 mean levels were measured. Results: Only two (4%) subjected to combination of clomiphene citrate and Gonal-f became pregnant. Combination of clomid and Gonal-f yielded better pre-ovulatory endometrial thickness and higher pre-ovulatory estradiol 2 mean levels for all cases. Conclusions: Combination of clomid and Gonal-f attained better results.

Clomid Gonal-f differentiated follicles endometrial thickness estradiol 2

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