Role of Vitamin E in Prevention of Breast Cancer: An Epidemiological Review
Md. Sajjadul Haque Ripon, Mohammad Asadul Habib, Miraz Hossain, Nadim Ahmed, Tanbir Kibria, Shirajum Munira, Kamrul Hasan
Asian Journal of Advanced Research and Reports · pp. 37–47 · Published 1 Jul 2020
10.9734/ajarr/2020/v11i330266Abstract
Breast cancer rates are so high among women in more developed countries, rates are increasing in almost every region of the world. In 2018, it is reported that 627,000 women died from breast cancer. Vitamin E is a common supplement characterized by its antioxidant potential effects on many chronic conditions that prevent free radicals from harming DNA, protein and cell membranes may serve as a part of cancer growth by reducing oxidative DNA alteration. The major forms of vitamin E as an anticancer agent, which acts as major antioxidants to regulate peroxidation reactions and control free-radical production within the body, are tocopherols and tocotrienols. Since Vitamin E had first acted as a non-antioxidant, α-tocopherol has inhibited smooth muscle proliferation activity and protein kinase C activity. Although tocotrienols are mostly investigated as antioxidant effects of tocotrienol, which plays an important role in reducing the damage to DNA by decreasing the by-product of lipid peroxidation. This study aims to investigate the connection between vitamin E and also the risk of breast cancer and the outcome is that some inverse relationship between vitamin E and breast cancer exists. There has been clear evidence that vitamin E reduces the risk of human cancer but our main focus is on breast cancer, seen in many prospective and retrospective case-control, cohort and intervention studies.
References (41)
- 1 Oxygen toxicity, oxygen radicals, transition metals and disease [DOI]
- 2 Free Radicals, Antioxidants in Disease and Health [DOI]
- 3 Biology of disease: free radicals and tissue injury.
- 4 Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers [DOI]
- 5 Vitamin E: function and metabolism [DOI]
- 6 Present Knowledge in Nutrition. [DOI]
- 7 Role of antioxidants in prophylaxis and therapy: A pharmaceutical perspective [DOI]
- 8 Role of oxygen free radicals in cancer development [DOI]
- 9 Oxy-radicals and cancer [DOI]
- 10 “Westernizing” Women's Risks? Breast Cancer in Lower-Income Countries [DOI]
- 11 Oxidative mechanisms in carcinogenesis [DOI]
- 12 Dietary Natural Products for Prevention and Treatment of Liver Cancer [DOI]
- 13 Vitamin E and cancer: An insight into the anticancer activities of vitamin E isomers and analogs [DOI]
- 14 Antiproliferative and Apoptotic Effects of Tocopherols and Tocotrienols on Preneoplastic and Neoplastic Mouse Mammary Epithelial Cells [DOI]
- 15 Cancer-preventive activities of tocopherols and tocotrienols [DOI]
- 16 Vitamin E: Food Chemistry, Composition, and Analysis
- 17 γ‐Tocopherol‐enriched mixed tocopherol diet inhibits prostate carcinogenesis in TRAMP mice [DOI]
- 18 Serum Beta-Carotene, Vitamins a and E, Selenium, and the Risk of Lung Cancer [DOI]
- 19 Inhibition of cell proliferation by alpha-tocopherol. Role of protein kinase C. [DOI]
- 20 Premenopausal Breast Cancer Risk and Intake of Vegetables, Fruits, and Related Nutrients [DOI]
- 21 Induction of apoptosis in human breast cancer cells by tocopherols and tocotrienols [DOI]
- 22 Tocotrienols inhibit the growth of human breast cancer cells irrespective of estrogen receptor status [DOI]
- 23 Role of lipids, lipoproteins and vitamins in women with breast cancer [DOI]
- 24 Prospective Study of Serum Vitamin E Levels and Esophageal and Gastric Cancers [DOI]
- 25 Oral mucositis in patients treated with chemotherapy for solid tumors: a retrospective analysis of 150 cases [DOI]
- 26 The exploding worldwide cancer burden [DOI]
- 27 A γ-tocopherol-Rich Mixture of Tocopherols MaintainsNrf2Expression in Prostate Tumors of TRAMP Mice via Epigenetic Inhibition of CpG Methylation, [DOI]
- 28 Potential role of tocotrienols in the treatment and prevention of breast cancer [DOI]
- 29 Intake of selected micronutrients and the risk of breast cancer [DOI]
- 30 DIET, PLASMA LEVELS OF BETA-CAROTENE AND ALPHA-TOCOPHEROL, AND RISK OF MALIGNANT MELANOMA [DOI]
- 31 Dietary α‐, β‐, γ‐ and δ‐tocopherols in lung cancer risk [DOI]
- 32 RETRACTED: Design, synthesis, and antioxidant potency of novel α-tocopherol analogues in isolated membranes and intact cells [DOI]
- 33 Plasma retinol, β-carotene and vitamin E levels in relation to the future risk of breast cancer [DOI]
- 34 Serum vitamin E, serum selenium and the risk of gastrointestinal cancer [DOI]
- 35 Breast cancer prevention by supplemental vitamin E. [DOI]
- 36 Serum Vitamin E Level and Risk of Female Cancers [DOI]
- 37 Membrane transfer of alpha-tocopherol. Influence of soluble alpha-tocopherol-binding factors from the liver, lung, heart, and brain of the rat. [DOI]
- 38 Dietary Intake of Nitrate Relative to Antioxidant Vitamin in Relation to Breast Cancer Risk: A Case-Control Study [DOI]
- 39 Photosensitization by antitumor agents, 4. Anthrapyrazole-photosensitized formation of single strand-breaks in DNA [DOI]
- 40 A prospective study of the relationship between serum vitamins A and E and risk of breast cancer [DOI]
- 41 Prospects for the chemoprevention of breast cancer [DOI]
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