Genetic Polymorphisms of GSTM1 and GSTT1 Genes and Susceptibility to Acute Lymphoblastic Leukemia in the Yemeni Population
Radfan Saleh, Hassan Hussein Musa, Gamal Abdul Hamid, Muzamil M. Abdel Hamid
Asian Hematology Research Journal · pp. 43–51 · Published 5 Apr 2022
Abstract
Background: GSTs (glutathione S-transferases) are enzymes that are well known for their capacity to detoxify hazardous substances. Previous research has found a link between GST polymorphisms and acute lymphoblastic leukaemia (ALL). The outcomes differed depending on the study and population. Objectives: To analyze the relation between polymorphisms of glutathione s-transferase Mu (GSM1) and glutathione s-transferase theta (GSTT1) genes and susceptibility to acute lymphoblastic leukemia (ALL). Methods: A total of 115 patients with ALL who attended oncology centers in Yemen and 140 unrelated apparently healthy individuals as the control group were recruited in this case-control study. DNA was extracted from EDTA venous blood samples and analyzed by Multiplex PCR for detection of the polymorphic deletion of the GSTT1 and GSTM1 genes. Results: The GSTT1 null genotype were found to increase the risk of acute lymphoblastic leukemia, (OR=2.649, 95%CI=1.589-4.416, p=0.000). The GSTM1 null genotype was not significant (p=0.076), however is risk for ALL (OR=1.481, 0.902-2.431). The combination effects of GSTT1null and GSTM1null were associated with the susceptibility to acute lymphoblastic leukemia (OR 3.396, 95% CI 1.832-6.297) (p =0.000). Conclusion: Susceptibility to ALL appears to be significantly related to GSTT1 null polymorphism but not to GSTM1 polymorphism in Yemeni population.
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