Functionalization of C=C Double Bonds of Pyrimidino-pyranoside Platform Groups

Abstract

In the search for peptidomimetic structures capable of mimicking endogenous peptides, we have studied the reactivity of C=C double bonds of pyrimidino-pyranoside platform groups. The exploitation of this reactivity by ozonolysis and reductive amination reactions allowed us to develop a fast and efficient route for the introduction of amine function capable of mimicking bioactive peptides.