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Research Article Open access CC BY 4.0

Serum Uric Acid Level as a Prognostic Factor in Benign Essential Tremor

Koçer Abdulkadir, Okay Münevver, Hasirci Buse, Ağırcan Dilek, VaroÄŸlu Asuman

Journal of Advances in Medicine and Medical Research · pp. 604–610 · Published 12 Mar 2015

10.9734/BJMMR/2015/15960

Abstract

Objective: Decreased serum uric acid has been associated with neurodegenerative diseases such as Parkinson’s disease (PD) in the elderly. Several studies suggest that there may be a link between PD and Essential tremor (ET) which is thought to be a neurodegenerative disease. Serum uric acid level (UA) and its relationship with prognosis in ET patients have not been addressed. Study Population: The current study was conducted in the outpatient neurology unit of Istanbul Medeniyet University Medical Faculty Göztepe Teaching Hospital between May 2011 and Sep 2013. Methods: Subjects with ET were evaluated. We collected serum samples to determine biochemical indicators including UA, glucose, blood lipids, liver function, and renal function. All the patients with vascular risk factors, dementia, depression or other neurodegenerative disorders were excluded, as were the subjects on uric acid-lowering therapy or with serious illnesses such as severe anemia, chronic renal failure, hepatic disease or active or ongoing cardiovascular or cerebral vascular disease. One hundred and sixteen subjects (52 isolated ET patients and 64 healthy controls well matched in comparison of age and sex) were enrolled. Results: UA level was similar between the groups. Follow-up UA levels of the patients were similar to controls, too. UA level correlated to age, ET starting age, cholesterol level and creatinine level (p<0.05). Conclusion: There were reasonable epidemiological evidences to support a link between ET and UA level, but we did not find any difference between serum UA levels of ET patients and controls in follow-up. Age was one of the factors contributing to the increased content of UA in the blood serum of especially the man with ET. These findings also supported the knowledge about isolated form of ET which was stable and benign.

Essential tremor Parkinson’s disease neurodegenerative disease uric acid age

References (30)

  1. 1 Consensus Statement of the Movement Disorder Society on Tremor [DOI]
  2. 2 Neuropathological changes in essential tremor: 33 cases compared with 21 controls [DOI]
  3. 3 How common is the most common adult movement disorder? Estimates of the prevalence of essential tremor throughout the world [DOI]
  4. 4 Animal Models of Action Tremor [DOI]
  5. 5 Uric acid and the development of metabolic syndrome in women and men [DOI]
  6. 6 Elevated serum uric acid levels in metabolic syndrome: an active component or an innocent bystander? [DOI]
  7. 7 Correlates of functional disability in essential tremor [DOI]
  8. 8 Risk of incident Parkinson's disease and parkinsonism in essential tremor: a population based study [DOI]
  9. 9 Essential tremor — Neurodegenerative or nondegenerative disease towards a working definition of ET [DOI]
  10. 10 Oxidative and nitrative protein modifications in Parkinson's disease [DOI]
  11. 11 Essential tremor: evolving clinicopathological concepts in an era of intensive post-mortem enquiry [DOI]
  12. 12 Urate: A Novel Biomarker of Parkinson‘s Disease Risk, Diagnosis and Prognosis [DOI]
  13. 13 Serum Uric Acid and Renal Prognosis in Patients with IgA Nephropathy [DOI]
  14. 14 Gout and risk of Parkinson disease [DOI]
  15. 15 Uric acid is reduced in the substantia nigra in parkinson's disease: Effect on dopamine oxidation [DOI]
  16. 16 Serum uric acid levels in patients with Parkinson's disease: Their relationship to treatment and disease duration [DOI]
  17. 17 Uric acid in Parkinson's disease [DOI]
  18. 18 Clinical Subtypes of Essential Tremor [DOI]
  19. 19 Torpedoes in Parkinson's disease, Alzheimer's disease, essential tremor, and control brains [DOI]
  20. 20 Emergence of Parkinson's disease in essential tremor: A study of the clinical correlates in 53 patients [DOI]
  21. 21 Protection of midbrain dopaminergic neurons by the end‐product of purine metabolism uric acid: potentiation by low‐level depolarization [DOI]
  22. 22 The relationship between uric acid levels and Huntington's disease progression [DOI]
  23. 23 Association between Essential Tremor and Other Neurodegenerative Diseases: What Is the Epidemiological Evidence [DOI]
  24. 24 ‘Essential Tremor' or ‘the Essential Tremors': Is This One Disease or a Family of Diseases? [DOI]
  25. 25 Development and validation of biomarker classifiers for treatment selection [DOI]
  26. 26 Soluble Neuroprotective Antioxidant Uric Acid Analogs Ameliorate Ischemic Brain Injury in Mice [DOI]
  27. 27 Hypothetical membrane mechanisms in essential tremor [DOI]
  28. 28 Effect of amantadine in essential tremor: A randomized, placebo‐controlled trial [DOI]
  29. 29 Hyperuricemia and age
  30. 30 GOUT AND RISK OF PARKINSON DISEASE: A PROSPECTIVE STUDY [DOI]

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