Surgical Management of a Mandibular Odontogenic Keratocyst Using Enucleation and 5-Fluorouracil: A Case Report
A. B. Rai, Himanshu Gupta, Nischal Gupta, Dorothy Jerian Dohling Wankhar
International Journal of Research and Reports in Dentistry · pp. 205–213 · Published 7 Apr 2026
10.9734/ijrrd/2026/v9i1291Abstract
Background: Odontogenic Keratocyst (OKC) is a developmental cyst known for its locally aggressive behavior and high recurrence rates. Traditional surgical management ranges from conservative enucleation to radical resection. The use of chemical adjuvants is critical to reducing recurrence while maintaining jaw function. Case Report: A 34-year-old female presented with pus discharge in the lower right posterior mandible. Clinical and radiographic examination revealed a large radiolucency in the right mandible (region 41-48). Fine Needle Aspiration Cytology (FNAC) and subsequent biopsy confirmed the diagnosis of an Odontogenic Keratocyst. The patient was managed with cystic enucleation and chemical curettage using 5-Fluorouracil (5-FU) ointment. Post-operative follow-up at 3 months showed satisfactory clinical healing with no neurosensory deficits. Radiographic evaluation confirmed progressive bone regeneration at the surgical site, with no evidence of recurrence.
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