Surgical Management of Odontogenic Keratocyst (OKC) with Chemical Cauterization Using Topical 5-Fluorouracil and Soft Tissue Reconstruction Using a Nasolabial Flap: A Case Report

Abstract

Aim: This case report evaluates the effectiveness of surgical enucleation with chemical cauterization using 5-fluorouracil (5-FU) and soft tissue reconstruction with a nasolabial flap in the management of odontogenic keratocyst (OKC). Study Design: Case Report. Place and Duration of Study: Department of Oral and Maxillofacial Surgery, C.S.M.S.S Dental College and Hospital, Chhatrapati Sambhajinagar, India with follow-up over 1.5 years. Methodology: A 52 year female patient underwent surgical enucleation of the OKC, followed by chemical cauterization of the cystic cavity using 5% 5-fluorouracil (5-FU) to minimize recurrence. Postoperatively, soft tissue dehiscence was identified and managed with reconstruction using an inferiorly based nasolabial flap to restore the intraoral soft tissue integrity. Results: The combined approach of enucleation, chemical cauterization with 5-FU, and nasolabial flap reconstruction resulted in successful management of the lesion, minimal recurrence risk, and satisfactory functional and aesthetic outcomes. Postoperative recovery with excellent healing observed in follow-ups over 1.5 year Conclusion: Surgical enucleation with adjunctive 5-FU chemical cauterization is a promising method for reducing OKC recurrence. The nasolabial flap is a versatile and reliable option for reconstructing small-to-moderate intraoral soft-tissue defects, even in cases with postoperative complications.