Skip to content
Research Article Open access CC BY 4.0

Symbiont Localization and Nature of Effector Molecules Generated in Malaria Vector-symbiont Relationships

Mulambalah Chrispinus Siteti, Siteti Darwin Injete

Microbiology Research Journal International · pp. 210–217 · Published 27 Mar 2015

10.9734/BMRJ/2015/16172

Abstract

The field of mosquito vector symbiosis is largely unexplored and yet it is likely that in the near future it will provide valuable opportunities for malaria control. Symbiont based malaria control approaches are gaining acceptance worldwide and there is need for detailed review to open up new research frontiers. Malaria vector symbionts localize in different parts of Anopheles mosquitoes and express proteins as effector molecules some with anti-Plasmodial effects. The types of effector molecules, their mode of action and site of action need to be elucidated. Microbial symbiotic species diversity and preferred locations in the malaria vector have not been adequately studied to understand the mode of transmission among vector species and from generation to generation. This is necessary for a better understanding of the behaviour and biology of symbionts before designing and executing symbiotic control strategies. The review highlights important developments in the dynamics of transmission of symbionts in malaria vector populations. The review forms a useful guide in the search and deployment of paratransgenic mosquitoes in symbiotic control of malaria. Aspects that require further elucidation by innovative research and new opportunities to exploit in malaria control are highlighted.

Microbial symbionts anti-Plasmodial effector molecules malaria vectors paratransgenesis symbiotic control

References (32)

  1. 1 Wolbachia: master manipulators of invertebrate biology [DOI]
  2. 2 Symbiont-mediated insecticide resistance [DOI]
  3. 3 Implication of the Mosquito Midgut Microbiota in the Defense against Malaria Parasites [DOI]
  4. 4 Bacteria of the genus Asaia stably associate with Anopheles stephensi , an Asian malarial mosquito vector [DOI]
  5. 5 New Hypothesis of the Cause of Cytoplasmic Incompatibility in Culex pipiens L. [DOI]
  6. 6 Diversity and function of bacterial microbiota in the mosquito holobiont [DOI]
  7. 7 The Genetics and Cell Biology of Wolbachia-Host Interactions [DOI]
  8. 8 Wolbachia Infections Are Virulent and Inhibit the Human Malaria Parasite Plasmodium Falciparum in Anopheles Gambiae [DOI]
  9. 9 Wolbachia Stimulates Immune Gene Expression and Inhibits Plasmodium Development in Anopheles gambiae [DOI]
  10. 10 Studies on Rickettsia-Like Micro-Organisms in Insects.
  11. 11 Bacterial diversity analysis of larvae and adult midgut microflora using culture-dependent and culture-independent methods in lab-reared and field-collected Anopheles stephensi-an Asian malarial vector [DOI]
  12. 12 Development of Transgenic Fungi That Kill Human Malaria Parasites in Mosquitoes [DOI]
  13. 13 Wolbachia: more than just a bug in insects genitals [DOI]
  14. 14 Bacteria in Midguts of Field-Collected Anopheles albimanus Block Plasmodium vivax Sporogonic Development [DOI]
  15. 15 Extraordinarily widespread and fantastically complex: comparative biology of endosymbiotic bacterial and fungal mutualists of insects [DOI]
  16. 16 Wolbachia and cytoplasmic imcompatibility in mosquitoes [DOI]
  17. 17 Infectious Speciation Revisited: Impact of Symbiont-Depletion on Female Fitness and Mating Behavior of Drosophila paulistorum [DOI]
  18. 18 Mosquito-Bacteria Symbiosis: The Case of Anopheles gambiae and Asaia [DOI]
  19. 19 Plasmodium falciparum: Inhibition of Sporogonic Development in Anopheles stephensi by Gram-Negative Bacteria [DOI]
  20. 20 Paternal transmission of symbiotic bacteria in malaria vectors [DOI]
  21. 21 Viral Paratransgenesis in the Malaria Vector Anopheles gambiae [DOI]
  22. 22 Bacteria of the Genus Asaia: A Potential Paratransgenic Weapon Against Malaria [DOI]
  23. 23 Targeting Plasmodium ligands on mosquito salivary glands and midgut with a phage display peptide library [DOI]
  24. 24 Biotechnology, physiology and genetics of the yeast Pichia anomala [DOI]
  25. 25 Cuticle-degrading enzymes of entomopathogenic fungi: Cuticle degradation in vitro by enzymes from entomopathogens [DOI]
  26. 26 Symbiotic control of mosquito borne disease [DOI]
  27. 27 Secretion of Anti-Plasmodium Effector Proteins from a Natural Pantoea agglomerans Isolate by Using PelB and HlyA Secretion Signals [DOI]
  28. 28 Different mosquito species host Wickerhamomyces anomalus (Pichia anomala): perspectives on vector-borne diseases symbiotic control [DOI]
  29. 29 The Virulent Wolbachia Strain wMelPop Efficiently Establishes Somatic Infections in the Malaria Vector Anopheles gambiae [DOI]
  30. 30 XVIII. Effect of a killer toxin of Pichia anomala to Pneumocystis. Perspectives in the control of pneumocystosis [DOI]
  31. 31 Distribution of mosquito (Diptera: Culicidae) species and Wolbachia (Rickettsiales: Rickettsiaceae) infections during the bird immigration season in Pathumthani province, central Thailand [DOI]
  32. 32 Killer anti-idiotypes in the control of fungal infections.

Cited by 0

No indexed citations yet.

Related research

Article metrics

Real usage data collected on this platform.

39

Page views

0

PDF downloads

9

Outbound clicks

0

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.