NSTEMI and Coronary Amyloid Infiltration: Challenges and Therapeutic Strategies in CHU Ibn Rochd, Casablanca

Abstract

Acute coronary syndromes (ACS) are major cardiovascular emergencies requiring prompt and appropriate management to reduce complications and improve prognosis. We report an unusual case of high-risk non-ST-segment elevation myocardial infarction (NSTEMI) in a 63-year-old patient with hypertrophic cardiomyopathy (HCM) and coronary amyloid infiltration. Cardiac investigations revealed severe triple-vessel coronary artery disease with myocardial necrosis sequelae, leading to the recommendation for coronary artery bypass grafting (CABG). This rare association complicates management due to structural alterations from amyloid infiltration, increasing ischemic and arrhythmic risks. This case highlights the importance of a multidisciplinary approach and rigorous follow-up to adapt therapeutic strategies to complex clinical presentations.