Biologic Activity of Novel Benzimidazolone Acetamide Derivatives: In vitro Evaluation against Six Bacterial Strains

Abstract

The emergence of bacterial resistance requires research into new natural or synthetic molecules capable of overcoming this resistance. Heterocyclic compounds, due to their broad spectrum of biological activity, represent a promising avenue of research. This study evaluates the antibacterial activity of new synthesized compounds (Z1-Z6) derived from benzimidazole on 6 bacterial strains: Escherichia coli, Bacillus sp., Rhizobium sp., Rhizobium leguminozarum, Bradyrhizobium japonicum and Rhizobium tropici using the agar diffusion method. The results of this study revealed inhibitory activity against Escherichia coli and Bacillus sp., with the highest activity observed with Z2 against Escherichia coli. This accuracy of the results was determined using the double-dilution method, which allowed us to obtain the Minimum Inhibitory Concentration (MIC). Ciprofloxacin, confirmed the strain’s sensibility. These results highlight the potential of benzimidazole derivatives as candidates for the development of new antibacterial agents capable of circumventing resistance        mechanisms.