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Research Article Open access CC BY 4.0

The Effect of Malaria Disease on Liver Function in Children Below 5 Years of Age

Roseanne Adah Ikpeama, Chukwubike Udoka Okeke, Benjamin Nnamdi Okolonkwo, Clement Ugochukwu Nyenke, Chinonye Oluchi Ezenwaka

South Asian Journal of Research in Microbiology · pp. 13–18 · Published 23 Dec 2023

10.9734/sajrm/2023/v17i4335

Abstract

Malaria continues to be a major global health concern in tropical regions, especially affecting children between the ages of 1 and 5. The aim of this study is to assess the influence of malaria on hepatocellular function in this vulnerable age group. The enrollment of 582 randomly selected children was approved ethically, and parental consent was obtained. Of these, 396 were in the test group (who tested positive for malaria), and 186 were in the control group (apparently healthy). Giemsa-stained thin and thick films were used to confirm the diagnosis of malaria, and serum markers such as SGOT, SGPT, ALP, and gamma glutamyl transferase were used to assess hepatocellular function while the malaria diagnosis was made. As further markers of liver health, albumin and protein levels were evaluated. The findings showed that, in comparison to the control group, children with malaria parasitemia had statistical significantly higher levels of ALP, SGOT, SGPT, and Gamma Glutamyl Transferase as well as lower levels of total protein and albumin (p < 0.05). This suggests a significant effect on liver function in children with malaria, ages 1 to 5. Finally, our research highlights the connection between liver impairment in young children and malaria parasitemia. To improve early detection and management of liver-related complications in affected children, we recommend adding hepatic function assessments to routine evaluations, especially in malaria-endemic areas.

Serum glutamic-oxaloacetic transaminase serum glutamic-pyruvic transaminase alkaline phosphatase gamma-glutamyl transferase

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