The Role of Hemic Hypoxia in the Development of Sensorineural Hearing Loss in Children Associated with Hepatitis B

Abstract

Background: There are not enough studies and evidenced researches conducted related to this topic. Therefore, we studied fetal haemoglobin in various somatic diseases in children with sensorineural hearing loss associated with hepatitis B. Materials and Methods: 26 children with sensorineural hearing loss associated with hepatitis B, aged from 5 to 18 years, were examined. The comparison group consisted of 8 children with sensorineural hearing loss without concomitant somatic pathology. The control group consisted of 12 healthy children. The compulsory examination plan for patients included generally accepted laboratory and instrumental diagnostic methods: complete blood count, urine, feces, Wasserman reaction, ECG. Results: Hb concentration in blood inpatient children with sensorineural hearing loss of the associated chronic hepatitis B (CHB) was reduced significantly by 58% compared with the healthy children. In children with Sensorineural Hearing Loss (CHT) without CHB, the studied parameter decreased when compared with healthy children by 25%. Analysis of the results showed a significant increase in the level of fetal haemoglobin in the blood of children with CHT associated with hepatitis B on average by 1.5 times, indicating hypoxia. Conclusion: Dependence of the indices of partial oxygen in the blood and, to a greater extent, HbF, on the blood content of the vasoconstrictor endothelin-1, von Willebrand factor, indicates the pathogenetic significance of the leading markers of endothelial dysfunction in the development of tissue hypoxia in children with sensorineural hearing loss combined liver disease.