Timing of Vaccination in Children after Intravenous Immunoglobulin Therapy for Kawasaki Disease

Abstract

The present study investigates the timing of vaccination in children after intravenous immunoglobulin therapy for Kawasaki disease. The specific type and timing of vaccinations following IVIG usage have been extensively studied both domestically and internationally, but there exist some discrepancies in Live Attenuated Vaccines (LAVs). Based on the analysis of recent research findings both domestic and international, we propose that for Kawasaki disease (KD) children receiving IVIG treatment, the recommended vaccination interval for LAVs. The diagnosis and treatment of KD in foreign countries mostly refer to the Sixth Revision of the Japanese Kawasaki Disease Diagnostic Guidelines, while China follows the Expert Consensus on the Diagnosis and Acute Treatment of Kawasaki Disease. At six months after IVIG therapy, the seroconversion rate for measles, mumps, rubella (MMR), and varicella after the initial vaccination was 88%, 6%, 78%, and 16% respectively, but at 9 months the seroconversion rate were over 90%. Therefore, the recommended vaccination interval for LAVs (MMR vaccine, MMR varicella, and varicella vaccine) should be 9 months in KD children.