Topical Delivery of Fenugreek Seed Extract Loaded Solid Lipid Nanoparticles Based Hydrogels for Alopecia
Journal of Pharmaceutical Research International · pp. 231–241 · Published 6 Aug 2021
10.9734/jpri/2021/v33i40A32239Abstract
Background: Alopecia, a chronic dermatological inflammatory condition affecting the hair follicles. Conventional treatments are associated with the risk of serious side effects. The stratum corneum limits the percutaneous absorption of drugs. Hence, the development of novel herbal formulations for topical delivery has been the target, with the enhancement of their therapeutic efficacy and safety of use. Aims: To formulate and characterize Fenugreek seed extract loaded solid lipid nanoparticles carrier for the management of Alopecia to reduce the systemic side effects. Methodology: Fenugreek seed extract loaded solid lipid nanoparticles (SLN) were prepared by melt emulsification accompanied by probe sonication. The formulation was prepared using GMS, Tween 80, and Soya lecithin as Lipid, Surfactant, and Co-Surfactant. The SLN was incorporated into carbapol 934 dispersion to convert it into a gel. The SLN formulation was evaluated for size, Polydispersity Index, Zeta Potential, Entrapment efficiency, Transmission Electron Microscopy. After that, the SLN gel was examined for Spreadability, Extrudabilty, Viscosity, In vitro drug release, Ex vivo permeation, and Skin deposition studies. Results: The formulated Fenugreek seed extract loaded showed a particle size of 223.36 nm with a narrow PDI of 0.313. Entrapment efficiency revealed that 74.56±0.12% of the drug was entrapped. Transmission electron microscopy images confirmed the spherical nature of the SLN. The extended-release pattern of the formulated SLN for 24h was observed in the in vitro release studies and followed Higuchi model(R2=0.9964). Ex vivo permeability showed a 72.05±0.15% deposition of Fenugreek seed extract loaded SLN. The formulation was stable for three months without significant changes. Conclusion: Fenugreek seed extract loaded NLC demonstrated enhanced permeation, improved skin retention, and extended release compared to conventional gel. The developed formulation would be further used for in vivo studies and by seeing above results it can be an alternative for Alopecia in the future.
Cited by 11
ANANTH PRABHU, MARINA KOLAND, JYOTHI D. · International Journal of Applied Pharmaceutics · 2024
Omar Awad Alsaidan, Ameeduzzafar Zafar, Rayan Hamood Al-Ruwaili · Artificial Cells, Nanomedicine, and Biotechnology · 2023
Department of Pharmaceutics, School of Pharmacy, RK University, Bhavnagar Highway, Kasturbadham, Rajkot - 360020, Gujarat, India, Ashish B Wadekar, Samir Atara · International Journal of Drug Delivery Technology · 2025
Poonam Kushwaha, Shazia Usmani, Mohd. Sufiyan · Naunyn-Schmiedeberg's Archives of Pharmacology · 2025
Kampanart Huanbutta, Napapat Rattanachitthawat, Anusorn Thampithak · Phytomedicine Plus · 2026
Mohammed F. Aldawsari, Md. Khalid Anwer · Salud, Ciencia y Tecnología · 2026
Rana E. Elnady, Manar S. Abdon, Hagar R. Shaheen · Pharmaceutics · 2025
Komal Padule, Sonali Shinde, Sohan Chitlange · Cosmetics · 2022
PRITAM KAYAL, R. RAGHUL, UDAYA KIRAN SAHOO · International Journal of Applied Pharmaceutics · 2025
Ritu Mishra, Neha Jain, Shreya Kaul · Drug Delivery and Translational Research · 2022
Showing 10 of 11 known citations — external sources report more than can currently be individually listed.
Related research
- Screening and Characterization of Biosurfactant Producing Bacteria from Soil Samples in Ogun-State, Nigeria — shares topic coverage
- Characterization and Biological Activities of an Alkali Soluble Exopolysaccharide from Acetobacter — shares topic coverage
- Production and Evaluation of Biosurfactant by Serratia marcescens UCP 1549 Using Industrial Wastes — shares topic coverage
- Preliminary Screening of Bio-surfactant Producing Bacteria Isolated from an Oil Contaminated Soil — shares topic coverage
- Production and Characterisation of Surfactant Produced by Bacillus subtilis and Its Anti Microbial Study — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
11
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.