Skip to content
Research Article Open access CC BY 4.0

Biological Studies of Pyrido [2, 3-d: 6, 5-d/] Dipyrimidine with Synthesis

M. Ismail Hossain, Md. Mosharef H. Bhuiyan, Ajoy Kumer

Asian Journal of Physical and Chemical Sciences · pp. 1–9 · Published 3 Apr 2018

10.9734/AJOPACS/2018/39709

Abstract

Fused pyrimidines,2,4,6,8-Tetrahydro-5-(4/-ethylphenyl)-10-aryl-2,4,6,8-tetraoxo-5H,10H-pyrido[2,3-d:6,5-d/]dipyrimidines, were prepared in good yield through a simple, clean and three-component one-pot cyclo-condensation reaction of a barbituric acid, aromatic aldehyde and 4-ethylaniline under reflex in a nitrogen atmosphere. The synthesized products were characterized by IR, NMR spectroscopy and elemental analyses are in good agreement with their expected molecular structure. All the compounds have been screened for their antimicrobial activity with four human pathogenic bacteria: Bacillus cereus, Salmonella typhi, Shigella dysenteriae, Listeria monocytogenes and four phytopathogenic fungi: Macrophomina phaseolina, Fusarium equiseti, Colletotrichum corchori and Alternaria alternata. The precursor barbituric acid was compared with the activity exhibited for the synthesized fused pyridopyrimidines, which show the increased inhibition against the bacterial growth after cyclization. The enhanced ability to inhibition may be due to the stability and aromaticity of heterocyclic synthesized in this study.  

Pyridopyrimidines antimicrobial activity barbituric acid inhibition disc diffusion method

Cited by 7

Green synthesis of pyrido[2,3-d:5,6-d′]dipyrimidine derivatives using modified g-C3N4 nanorods and study on their biological activity using computational approaches

Zahra Zare Josheghani, Leila Moradi · Journal of Molecular Structure · 2025

Synthesis, characterization, antimicrobial activity and computational exploration of ortho toludinium carboxylate ionic liquids

Ajoy Kumer, Wahab Khan · 2021

The substituent group activity in the anion of cholinium carboxylate ionic liquids on thermo-physical, chemical reactivity, and biological properties: A DFT study

Afroza Zannat, Ajoy Kumar, Mithun Sarker · 2019

Barbiturates: A Review of Synthesis and Antimicrobial Research Progress

Madhvi, Divya Utreja, Shivali Sharma · Current Organic Synthesis · 2022

The effect of alkyl chain and electronegative atoms in anion on biological activity of anilinium carboxylate bioactive ionic liquids and computational approaches by DFT functional and molecular docking

Ajoy Kumer, Md. Wahab Khan · Heliyon · 2021

Efficient p-Toluenesulfonic Acid-Catalyzed Synthesis of 5-Aryl-5,10-dihydropyrimido[4,5-b]quinoline-2,4(1H,3H)-diones and Their Antimicrobial Activity

Madhvi, D. Utreja, A. Kalia · Russian Journal of Organic Chemistry · 2022

Synthesis, characterization, antibacterial activity of thiosemicarbazones derivatives and their computational approaches: Quantum calculation, molecular docking, molecular dynamic, ADMET, QSAR

Mahbub Alam, Mohammed Nurul Abser, Ajoy Kumer · Heliyon · 2023

Related research

Article metrics

Real usage data collected on this platform.

0

Page views

0

PDF downloads

0

Outbound clicks

7

Citations

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

No views recorded yet.

Traffic sources

Referring site, by host.

No traffic recorded yet.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.