Green Synthesis of Derivatives of 2-Aminobenzothiazole as Novel Antimicrobials
Kaushal Kishor Prasad, K P Srivastava
International Research Journal of Pure and Applied Chemistry · pp. 73–81 · Published 10 Jan 2026
10.9734/irjpac/2026/v27i1974Abstract
A novel series of 2-(1,3-benzothiazol-2-ylcarbamoyl)-benzoic acid was synthesized by a one-pot reaction of 2-aminobenzothiazole with phthalic anhydride, using ionic liquid {1-butyl-3-methylimidazolium bisulfate, ([BMIM]+[HSO4]-)} as a green alternative to volatile organic solvents, an environmentally benign and economical solvent, with greater yields in shorter reaction times. The ecologically benign synthesized compounds were characterised using analytical and spectral analyses. The investigated compounds were screened for their antibacterial and antifungal activities for three different bacterial strains and two different fungal isolates, respectively. The biological evaluation indicates that they exhibit moderate antibacterial activity but lack antifungal activity.
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