Assessment of Thrombolytic Activity of Selected Species from Lamiaceae Family Growing Naturally in Kurdistan Region\Iraq Using In-vitro Model

Abstract

Aims: The present study was aimed to assess most commonly used medicinal plant belong to Lamiaceae family for their thrombolytic activity. Place and Duration of the Study: Pharmacy College\ Hawler Medical University, June, 2015. Methodology: Dried leaf part ethanolic extracts of selected species have been evaluated for their thrombolytic activity using fresh human blood specimen at concentrations of 200, 400, 600, 800 and 1000 µg\ml, streptokinase drug and distilled water were incorporated in the study as control positive and negative, respectively. Results: Showed significant thrombolytic activity of leaf extracts at all tested concentrations in comparison with control negative distilled water (P < 0.01), highest clot lysis activity were recorded for Salvia officinalis leaf extract (68.43±1.457%) and minimum activity were exhibited by Rosmarinus officinalis leaf extract (49.27±3.256%). Salvia officinalis and Thymus vulgaris expressed significant thrombolytic activity in comparison with control positive streptokinase            (P < 0.05) at highest tested dose concentration (1000 µg\ml). Conclusion: Selected species from Lamiaceae plant family can open a venue for production of thrombolytic drugs derived from natural source with greatest activity and lowest adverse effects.