Phenothiazine Group Drug Induced Corneal and Lenticular Deposits in a Patient of Severe Depression – A Case Report

Abstract

  A 50-yr-old man, who had been taking medication for severe depression with psychosis, presented to eye OPD of UPRIMS & R with a chief complaint of visual disturbance of 8 months duration. He was continuously taking chlorpromazine unsupervised in double the dose and doubles the frequency. Slit-lamp examination revealed fine, discrete, and brownish deposits on the posterior cornea. In addition, bilateral star-shaped anterior sub capsular lens opacities, which were dense, dust-like granular deposits, were noted. Best-corrected visual acuity was 6/36 in the right eye and 6/24 in the left eye. Other ocular findings were normal. Dark pigmentation on face was present. The deposition was not reversible even after stopping the drug.