An Over View of Chronotherapeutic Drug Delivery Systems Based on Floating Pulsatile Concept

Abstract

In the modern era of pharmaceutical research much attention has been focussed on patients’ health in terms of therapeutic efficacy and safety. The tradition of prescribing medication at evenly spaced time intervals throughout the day, in an attempt to maintain constant drug levels throughout a 24-hour period, may be changing as researchers' report that some medications may work better if their administration is coordinated with day-night patterns and biological rhythms. All these conditions pushed the formulation scientists to develop chronotherapeutic drug delivery system. This article focuses on different drug delivery systems its advantages and disadvantages, role of circadian rhythms in major risk occurring disorders, like joint pains in case of rheumatoid arthritis, cardiovascular diseases like angina pectoris, hypertension, myocardial infarction, pulmonary disorder like asthma and their treatment by conventional and novel pulsatile drug delivery systems.