Understanding the Relationship between Polycystic Ovarian Syndrome (PCOS) and Dyslipidemia
Chikadibia Fyneface Amadi, Benjamin Nnamdi Okolonkwo, Melody Igochiyerum George-Oparati, Kingsley Kalawari Odiabara
Asian Journal of Biochemistry, Genetics and Molecular Biology · pp. 1–11 · Published 10 Oct 2023
10.9734/ajbgmb/2023/v15i3333Abstract
Polycystic ovarian syndrome (PCOS) is a heterogenous disorder characterized by signs and symptom of androgen excess and ovarian dysfunction in the absence of other diagnosis, with a prevalence of ~6%-~20%. The aetiology of PCOS can either be unknown (primary) or originating from identifiable causes (secondary) like obesity, idiopathic hirsutism, epilepsy, androgen-secreting tumors etc. Weight gain especially around the stomach, missed, irregular or light menstruations, hyperandrogenism, infertility can serve as indicators for PCOS. This review is aimed at examining the relationship that exists between PCOS and dyslipidemia. With a prevalence report of about 70%, dyslipidemia, is related to PCOS, and its causes are multifactorial with many cases being undiagnosed due to different diagnostics criteria for PCOS. Studies revealed that women with PCOS showed increased levels of LDL-cholesterol, VLD Lipoprotein, ApoC-I, lipoprotein (a), decreased levels of HDL-cholesterol and ApoA-I while ApoB. Psychophysiology in dyslipidemia in PCOS include: obesity, hyperandrogenism. Insulin resistance. Diagnostic measures include: complete lipid profile test, pelvic ultrasound and transvaginal scan, hormone tests, glucose and insulin tolerance test, etc. There is no known cure of PCOS reported yet but there are different options on management which include lifestyle change, use of statin drugs if lifestyle modifications do not work, use of androgen inhibiting drugs and metformin might help. It is important and more advisable for the age range for PCOS testing to be reduced to accommodate females just entering puberty.
References (51)
- 1 Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS) [DOI]
- 2 Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan [DOI]
- 3 Impaired glucose tolerance, type 2 diabetes and metabolic syndrome in polycystic ovary syndrome: a systematic review and meta-analysis [DOI]
- 4 The physiology and clinical utility of anti-Müllerian hormone in women [DOI]
- 5 Scientific Statement on the Diagnostic Criteria, Epidemiology, Pathophysiology, and Molecular Genetics of Polycystic Ovary Syndrome [DOI]
- 6 Assessment of Cardiovascular Risk and Prevention of Cardiovascular Disease in Women with the Polycystic Ovary Syndrome: A Consensus Statement by the Androgen Excess and Polycystic Ovary Syndrome (AE-PCOS) Society [DOI]
- 7 Anti-Müllerian hormone: ovarian reserve testing and its potential clinical implications [DOI]
- 8 Prevalence and predictors of dyslipidemia in women with polycystic ovary syndrome [DOI]
- 9 Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis [DOI]
- 10 Familial hypercholesterolaemia [DOI]
- 11 Genetic, hormonal and metabolic aspects of PCOS: an update [DOI]
- 12 Lipoprotein Lipid Concentrations and Cardiovascular Risk in Women with Polycystic Ovary Syndrome [DOI]
- 13 Lipid levels in polycystic ovary syndrome: systematic review and meta-analysis [DOI]
- 14 Diagnosis of Polycystic Ovarian Syndrome: The Rotterdam Criteria Are Premature [DOI]
- 15 Insulin resistance, polycystic ovary syndrome, and type 2 diabetes mellitus [DOI]
- 16 Incidence and treatment of metabolic syndrome in newly referred women with confirmed polycystic ovarian syndrome [DOI]
- 17 PCOS, coronary heart disease, stroke and the influence of obesity: a systematic review and meta-analysis [DOI]
- 18 Definitions, prevalence and symptoms of polycystic ovaries and polycystic ovary syndrome [DOI]
- 19 Anxiety and depression in polycystic ovary syndrome: a systematic review and meta-analysis [DOI]
- 20 Overweight Women with Polycystic Ovary Syndrome Have Evidence of Subclinical Cardiovascular Disease [DOI]
- 21 Intramuscular testosterone esters and plasma lipids in hypogonadal men: a meta-analysis [DOI]
- 22 The Role of Genes and Environment in the Etiology of PCOS [DOI]
- 23 Evolution of Methods for Measurement of HDL-Cholesterol: From Ultracentrifugation to Homogeneous Assays [DOI]
- 24 Diagnostic Criteria for Polycystic Ovary Syndrome: Pitfalls and Controversies [DOI]
- 25 Pregnancy Complications in Women with Polycystic Ovary Syndrome [DOI]
- 26 Chronic testosterone treatment induces selective insulin resistance in subcutaneous adipocytes of women [DOI]
- 27 Role of Anti-Müllerian Hormone in pathophysiology, diagnosis and treatment of Polycystic Ovary Syndrome: a review [DOI]
- 28 The Effect of Atorvastatin in Patients with Polycystic Ovary Syndrome: A Randomized Double-Blind Placebo-Controlled Study [DOI]
- 29 Difference in body weight between American and Italian women with polycystic ovary syndrome: influence of the diet [DOI]
- 30 Relation of intra-abdominal fat distribution to metabolic disorders in nonobese patients with polycystic ovary syndrome [DOI]
- 31 Obesity, lipids, cardiovascular risk, and androgen excess [DOI]
- 32 Atherogenic Lipoprotein Phenotype and Low-Density Lipoproteins Size and Subclasses in Women with Polycystic Ovary Syndrome [DOI]
- 33 Diagnosis of polycystic ovary syndrome: from NIH criteria to ESHRE-ASRM guidelines.
- 34 Milder forms of atherogenic dyslipidemia in ovulatory versus anovulatory polycystic ovary syndrome phenotype [DOI]
- 35 Atherogenic forms of dyslipidaemia in women with polycystic ovary syndrome [DOI]
- 36 Smaller LDL particle size in women with polycystic ovary syndrome compared to controls [DOI]
- 37 Medical therapy in women with polycystic ovarian syndrome before and during pregnancy and lactation.
- 38 Androgens in Polycystic Ovary Syndrome: The Role of Exercise and Diet [DOI]
- 39 Polycystic ovary syndrome is associated with atherogenic changes in lipoprotein particle number and size independent of body weight [DOI]
- 40 Assessing Insulin Sensitivity and Resistance in Humans
- 41 Metabolic Syndrome: Polycystic Ovary Syndrome.
- 42 Prevalence, Pattern and Predictors for Dyslipidemia of Chinese Women With Polycystic Ovary Syndrome [DOI]
- 43 Free testosterone, luteinizing hormone/follicle stimulating hormone ratio and pelvic sonography in relation to skin manifestations in patients with polycystic ovary syndrome [DOI]
- 44 Can serum apolipoprotein C-I demonstrate metabolic abnormality early in women with polycystic ovary syndrome? [DOI]
- 45 Atherogenic changes in low-density lipoprotein particle profiles were not observed in non-obese women with polycystic ovary syndrome [DOI]
- 46 LDL Species Heterogeneity in the Atherogenic Dyslipidemia of Polycystic Ovary Syndrome [DOI]
- 47 … About polycystic ovarian syndrome [DOI]
- 48 Pharmacotherapy: A Pathophysiologic Approach [DOI]
- 49 Black's Medical Dictionary [DOI]
- 50 Can Polycystic Ovarian Syndrome be cured? Unfolding the Concept of Secondary Polycystic Ovarian Syndrome! [DOI]
- 51 Microglia: sculptors of the polycystic ovary syndrome (PCOS)-like brain? [DOI]
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