A 4-Week Period of Administration of Fenugreek Oil or Metformin Improve Cardiac and Renal Complications in Metabolic Syndrome‐Induced Rats
Eman Adel Zayed, Afaf A. Ain Shoka, Kamal A. El Shazly, Aliaa E. M. K. El-Mosallamy, Ahmed Adel Zayed, Hekma A. Abd El Latif
Asian Journal of Cardiology Research · pp. 53–64 · Published 6 Apr 2021
Abstract
Background: Frequent consumption of fructose and saturated fatty acids increase risk of metabolic syndrome (MS). Features of MS include insulin resistance, dyslipidemia, visceral obesity, and hypertension. Aim: The aim of this study was to investigate the role of fenugreek oil and metformin in ameliorating features of MS. Methods: Induction of MS in rats by high‐fructose high‐fat fed diet was certain after 8 weeks. Animals were divided into four groups: normal control, MS control group given saline, MS groups given fenugreek oil (4 ml/kg), and metformin (100 mg/kg) daily for 4 weeks. Blood pressure, heart rate, creatine kinase-MB, and lactate dehydrogenase were estimated. Also renal function and antioxidant activity were evaluated. In addition, to C-reactive protein, and fibrinogen determined. Results: Fenugreek oil and metformin caused decrease in both MS‐induced increase in blood pressure and heart rate. They reduced creatinine, blood urea nitrogen, uric acid, albumin, and MDA with increased Glutathione, and superoxide dismutase. Drugs also decreased C-reactive protein, and fibrinogen compared with MS control group. Conclusion: Fenugreek oil and metformin ameliorate cardiac and renal complication of MS via their antioxidant activity
Cited by 0
No indexed citations yet.
Related research
- Metabolic Syndrome among Healthcare Workers in a Tertiary Hospital in South-South, Nigeria — shares topic coverage
- Cortisol and Metabolic Syndrome Components in Obese and Overweight Young Adults of a Nigerian Private University — shares topic coverage
- Metabolic Syndrome and Kidney Damage: Prevalence and Assessment of Risk among Apparently Healthy Resident of Ado Ekiti, South West Nigeria — shares topic coverage
- Vitamin D and Insulin Resistance in Metabolic Syndrome — shares topic coverage
- Metabolic Syndrome and Its Association with Nutritional and Cardiometabolic Risk Factors: Prevalence among Apparently Healthy Adults in a Rural Community in Southwestern Nigeria — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
0
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.