Tissue Protein Carbonylation in Aging: A Strategic Analysis of Age-Related Protein Modification
T. A. Kolawole, O. N. Ilochi, B. O. Oluwatayo, A. N. Chuemere, D. V. Dapper
Journal of Advances in Medical and Pharmaceutical Sciences · pp. 1–5 · Published 16 May 2019
10.9734/jamps/2019/v20i330111Abstract
Free radicals generated in a variety of biological systems have been implicated in mechanisms of aging and age-related pathologies. This study strategically revealed the varying levels of carbonylated proteins in 3 different tissues of 40 wistar rats of varying ages. Their ages include 25-30, 45-50 and 65-70 days. The brain, heart and kidney tissue homogenates were prepared and biochemically analyzed for products of protein oxidation using 2,4-dinitrophenylhydrazones and autoantibodies against carbonylated proteins. This study revealed a direct proportional relationship between age and protein carbonylation in brain, heart and kidney tissue homogenates. The level of carbonylated proteins were significantly (P≤0.05) increased in the assayed tissues as all test groups advanced in age. Oxidative modification of proteins in brain and kidney tissues showed similar trend. This age-related biochemical manifestation may be as a result of increased generation of free radicals at mitochondrial level or decreased anti-oxidant defenses as living organisms advance in age.
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