Microwave-Assisted Synthesis, NMR, and  Cyclic Voltammetric Study of Some Novel 3,5-Disubstituted 1H-1,2,4-Triazoles Containing  Hetaryl Fragments

Yaseen A. Al-Soud; Ziad Moussa; Ali F. Al-Ghamdi

doi:10.9734/ACSJ/2014/12036

Research Article Open access CC BY 3.0

Microwave-Assisted Synthesis, NMR, and Cyclic Voltammetric Study of Some Novel 3,5-Disubstituted 1H-1,2,4-Triazoles Containing Hetaryl Fragments

Yaseen A. Al-Soud, Ziad Moussa, Ali F. Al-Ghamdi

Chemical Science International Journal · pp. 1001–1013 · Published 23 Aug 2014

10.9734/ACSJ/2014/12036

Abstract

The synthesis of the title compounds 5a-c has been accomplished by a Suzuki cross coupling reaction between arylbromide 3 and 5-Indole boronic acid to furnished precursor 4, which was used as a key intermediate for the synthesis of the preceding targets. Thus, treatment of 4 with variously-substituted arylsulfonyl chlorides, the sulfonate derivatives 5a-c were obtained in good yields and high purity. The structures of 5a-c were characterized by 1H, 13C NMR, and liquid chromatography-mass spectroscopy techniques. Further, the electrochemical behavior of compound 5c has been investigated by cyclic voltammetry using Britton-Robinson (B-R) buffer at pH 3, pH 7 and pH 9, acetate buffer pH 3, and Phosphate buffer pH 3. A broad anodic cyclic voltammetric wave at Eap= 640 mV was observed.

Synthesis suzuki cross coupling 1, 2, 4-triazoles cyclic voltammetry

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Yaseen A. Al-Soud, Ziad Moussa, Ali F. Al-Ghamdi (2014). Microwave-Assisted Synthesis, NMR, and Cyclic Voltammetric Study of Some Novel 3,5-Disubstituted 1H-1,2,4-Triazoles Containing Hetaryl Fragments. Chemical Science International Journal , 1001–1013. https://doi.org/10.9734/ACSJ/2014/12036

Affiliations

Yaseen A. Al-Soud — Department of Chemistry, Faculty of Science, Taibah University, Al-Madinah Al-Munawwarah, Saudi Arabia and Home Address: Department of Chemistry, Faculty of Science, Al Al-Bayt University, Al-Mafraq, Jordan
Ziad Moussa — Department of Chemistry, Faculty of Science, Taibah University, Al-Madinah Al-Munawwarah, Saudi Arabia
Ali F. Al-Ghamdi — Department of Chemistry, Faculty of Science, Taibah University, Al-Madinah Al-Munawwarah, Saudi Arabia

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