Extended Spectrum β-Lactamases among Enterobacteriaceae Isolated from Clinical Specimens of a Tertiary Hospital in 2014

Abstract

Extended spectrum beta-lactamase producing Enterobacteriaceae have become widespread among hospitals and even in the community. Such phenomenon poses a therapeutic dilemma against certain antimicrobial drugs that limit therapeutic options. This study was conducted to evaluate the prevalence of ESBL producing Enterobacteriaceae in a tertiary hospital in Bacolod City and their antibiotic resistance profile for the year 2014. Out of 662 isolates, 125 (18.89%) were found to be ESBL producing and were frequently seen in Escherichia coli (4.96%), Klebsiella pneumoniae (4.08%) and Enterobacter aerogenes (3.36%). Urine was found to be the most common specimen to contain this type of bacteria (7.70%), followed by wounds and abscess (5.14%), and sputum (3.63%). These isolates were also found to be least resistant to amikacin with 10.5% followed by imipenem and meropenem with 17.1% and 15.4% respectively. Furthermore, there was no significant difference with regard to sex, but with significant difference in terms of age.