QSAR Study of 3-Phenylamino-1,4-naphtoquinones Anti-cancer Activities
International Research Journal of Pure and Applied Chemistry · pp. 1–6 · Published 27 Dec 2016
10.9734/IRJPAC/2016/30468Abstract
Aims: Evaluation the impact of quinones containing alkylamio groups upon biological activities and extent of napthoquinones based upon QSAR technique. Study Design: QSAR Approach. Place and Duration of Study: Data were collected from literature. Methodology: About eleven naphthoquinones which have cytotoxic effect against DU145 Cancerous, MCF7 Cancerous and T24 Cancerous and 6 descriptors were used to find good QSAR model. Results: The biological activity and surface tension of aminophenylnaphthoquinones can be modeled with linear regression with negative coefficient and satisfied statistical data for DU145 Cancerous r2=0.662, F=17.646, and s=0.34033 Conclusion: The inhabitation of DU145 Cancerous is influenced by surface tension.
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