Kinetic Spectrophotmetric Method for Quantitation of Rizatriptan Benzoate in Pharmaceutical Formulations
S. Malini, Kalyan Raj, M. A. Veena, N. Nanda
International Research Journal of Pure and Applied Chemistry · pp. 1–11 · Published 2 Jul 2015
10.9734/IRJPAC/2015/17935Abstract
A simple, sensitive and accurate kinetic spectrophotometric method for the determination of Rizatriptan Benzoate in pure and dosage form is described. The method is based on spectro-photometrically monitoring the oxidation of the drug by a known excess of Chloramine-B in HCl medium using initial rate, fixed time and variable time method in HCl medium. The oxidized product exhibits a maximum absorption at 490nm. The apparent molar absorptivity and Sandell’s sensitivity values are in the range 2.97x104 to 0.0198 respectively. The proposed method has been successfully applied to the determination of RTB in commercial pharmaceutical formulations. Statistical comparison of the results with well established reported method shows agreement in terms of precision and accuracy.
Cited by 0
No indexed citations yet.
Related research
- Assessment of Hygienic Effects of Laundering Using Spectrophotometry — shares topic coverage
- Spectrophotometric and Conductometric Study of Methyl Orange - Cetylpyridinium Chloride Ion Pair in Aqueous Solution — shares topic coverage
- Quantification of Total Flavonoids and Phenolic Acids from Microwave Irradiated and Non-irradiated Plants — shares topic coverage
- FTIR and UV-Visible Spectrophotometric Derivatization Studies of Artemether — shares topic coverage
- Analyses of Species of Phosphorus in Four Selected Streams within Abakaliki, Metropolis, Nigeria — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
0
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.