Administration of Exosome-based Treatment for Exogenous Ochronosis Caused by Prolonged Use of Topical Hydroquinone

Abstract

Objective: Exogenous ochronosis is a rare but challenging skin condition caused by prolonged misuse of hydroquinone-containing creams, with limited effective treatments. This study aimed to evaluate the effectiveness of exosome-based therapy as a novel therapeutic approach for this condition. Materials and Methods: A 39-year-old Indonesian woman with stage 2 exogenous ochronosis, characterized by discoloration and skin dullness following eight months of hydroquinone misuse, was treated with plant-derived exosomes administered via intradermal injection and topical serum application. Results: After 36 days of treatment, the patient showed marked improvements in skin texture, hydration, and a reduction of hyperpigmentation and telangiectasia, with no adverse effects observed. Conclusion: This case highlights the potential of exosome therapy as an effective and minimally invasive intervention for exogenous ochronosis. The findings highlight the need for further research to validate this approach and reinforce the importance of stricter regulations to prevent dermatological complications from harmful skincare ingredients.