Alterations of Tumor Suppressor Genes Expression in Colorectal Cancer: Their Impact on Progression and Prediction of Patients Outcome
Menha Swellam, Tamer E. Mosa, Mie Afify, Mohamed D. E. Abdelmaksoud, Lobna R. Ezz El Arab
Asian Journal of Research in Biochemistry · pp. 1–11 · Published 5 Apr 2018
10.9734/ajrb/2018/v2i1394Abstract
Background: Deregulation of tumor suppressor genes as APC, DCC and SMAD2 are related to tumorgenesis thus we aimed to investigate their expression among colorectal cancer to validate their relation with clinicopathological factors and the clinical outcome for CRC patients. Materials and Methods: Formalin-fixed paraffin samples from 115 colorectal cancer were investigated for APC, DCC and SMAD2 gene expression using quantitative PCR (QPCR) and their levels were analyzed versus clinicopathological factors and the overall survival (OS) of colorectal cancer patients. Results: A significant relation was reported between DCC and SMAD2 gene expression with clinical stages as they reported decrease expression among those with stage III. The three investigated genes were decreased significantly with poor histological differentiation colorectal cancer patients. The correlations between the expressions of the investigated genes revealed a significant correlation between SMAD2 and APC as well as between SMAD2 and DCC. Moreover patients with mean levels below and equal their expression values showed a considerable difference with OS. Conclusion: Gene expression of tumor suppressor genes APC, DCC and SMAD2 were significantly related to differential grading and patient's outcome thus pointing out their potential role as predictive markers for prognosis of colorectal cancer.
Cited by 0
No indexed citations yet.
Related research
- Colorectal Cancer Risk and Prevention Knowledge among Adults Attending Public Health Facilities in Obudu, Cross River State, Nigeria — shares topic coverage
- The Use of Complete Blood Count as Inflammatory Biomarkers in Patients with Colorectal Cancers in Enugu State University of Science and Technology Teaching Hospital, Parklane Enugu — shares topic coverage
- Demographic and Histopathological Spectrum of Gastrointestinal Cancers Excluding Hepatobiliary System: A 10-Year Review from Makurdi, North Central Nigeria — shares topic coverage
- Fecal and Salivary Microbial Gene Markers for the Non-invasive Detection of Colorectal Cancer Progression — shares topic coverage
- Can Noninvasive Tests Substitute Endoscopy for Diagnosis of Colonic Diseases? — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
0
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.