Effect of Methanolic Leaf Extract of Carica papaya on Plasmodium berghei Infection in Albino Mice
Ishaya Y. Longdet, Emmanuel A. Adoga
European Journal of Medicinal Plants · pp. 1–7 · Published 14 Aug 2017
10.9734/EJMP/2017/34698Abstract
Aim: The work was designed to investigate the antmalarial activity of methanolic leaf extract of Carica papaya on Plasmodium berghei NK65 strain infection in vivo. Place and Duration of Study: Department of Biochemistry and National Institute of Pharmaceutical Research and Development, Abuja, Nigeria, between August and October 2016. Materials and Method: Twenty five mice were intraperitoneally infected with chloroquine sensitive P. berghei strain and shared into 5 equal groups. Group 1 mice were infected and administered only normal saline (negative control). Groups 2, 3 and 4 were treated, after infection, with 100, 200 and 400 mg extract/kg body weight of mouse respectively while group 5 was treated with 5 mg chloroquine /kg body weight. The phytochemical constituents of the plant extract were evaluated. Result: The extract produced a dose dependent decrease in the level of parasitaemia when compared to the negative control group. Also, at doses of 200 mg/kg and 400 mg/kg, the extract produced increase in body weight and PCV of the infected mice as compared to mice in the negative control group. Phytochemical screening showed that the leaf extract contains alkaloids, anthraquinones, tannins, flavonoids, saponins cardiac glycosides and steroids. Conclusion: the methanolic leaf extract of Carica papaya presented a good effect on Plasmodium infection in mice and so could serve as a possible source of antimalarial compounds.
Cited by 9
Ashutosh Sharma, Archana Bachheti, Priyanka Sharma · Current Research in Biotechnology · 2020
Arwansyah Arwansyah, Sitti Rahmawati, Siti Nuryanti · Phytomedicine Plus · 2025
AMI TJITRARESMI, MOELYONO MOEKTIWARDOYO, YASMIWAR SUSILAWATI · International Journal of Applied Pharmaceutics · 2021
Akinpelu Moronkeji, Ikechi Gerald Eze, Ronald Ayodele Bejide · Journal of Medicinal Plants Research · 2018
Mohini Shelke, Avesh Tamboli, Pankaj Sonawane · Research Journal of Pharmacognosy and Phytochemistry · 2021
Pierre Lutgen · Pharmacy & Pharmacology International Journal · 2018
Weerakit Taychaworaditsakul, Chalermpong Saenjum, Nongkran Lumjuan · Toxics · 2024
Rachel Omagha, Emmanuel Taiwo Idowu, Chibuisi Gideon Alimba · Journal of Parasitic Diseases · 2021
Surya P. Singh, Sanjay Kumar, Sivapar V. Mathan · DARU Journal of Pharmaceutical Sciences · 2020
Related research
- ABO Blood Groups and Malaria Prevalence in a Referral Hospital in Nigeria — shares topic coverage
- Prevalence of Malaria among Pregnant Women and Children Under Five Years in Abi Local Government Area, Cross River State, Nigeria — shares topic coverage
- A Study on Relationship of Thrombocytopenia and Likelihood of Severe Malaria in Patients Admitted With Malaria in a Tertiary Care Hospital of Dakshina Kannada — shares topic coverage
- Platelet Alteration in Plasmodium vivax Malaria Patients in Thailand — shares topic coverage
- Patients’ Perception of Health Care Services in Malaria Endemic Area in Mali: Villages with Health Care Services Versus villages Without Health Care Services — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
9
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.