Michael reaction

Consecutive Four-Component Coupling-Addition Aza-Anellation Pictet–Spengler Synthesis of Tetrahydro-β-Carbolines: An Optimized Michael Addition and Computational Study on the Aza-Anellation Step

Kai Ries, Françoise A. Aouane & Thomas J. J. Müller · Organics · 2023

Starting from acid chlorides, alkynes, tryptamines, and acryloyl chloride, 21 densely substituted tetrahydro-β-carbolines were prepared in a four-component, one-pot reaction. In this study, the aza-Michael addition step to generate intermediate enaminones was optimized in the pre...

Open access Research Article 10.3390/org4030025

Thia-Michael Reaction under Heterogeneous Catalysis

Giovanna Bosica, Roderick Abdilla & Alessio Petrellini · Organics · 2023

Thia-Michael reactions between aliphatic and aromatic thiols and various Michael acceptors were performed under environmentally-friendly solvent-free conditions using Amberlyst® A21 as a recyclable heterogeneous catalyst to efficiently obtain the corresponding adducts in high yie...

Open access Research Article 10.3390/org4010007

Synthesis of 3-Hydroxy-9H-fluorene-2-carboxylates via Michael Reaction, Robinson Annulation, and Aromatization

Yu-Min Wang, Yi-Hung Liu & Shiuh-Tzung Liu · Organics · 2022

A series of 3-hydroxy-fluorene-2-carboxylate compounds were prepared from Michael addition of acetoacetate to 2-benzylideneindan-l-one followed by Robinson annulation and aromatization. In this reaction, we were able to isolate two Robinson annulation products and characterize th...

Open access Research Article 10.3390/org3040031