Objective: To determine the infective dose of Staphylococcus aureus (ATCC 29213) and Pseudomonas aeruginosa (ATCC 27853) in Sprague Dawley rats, when the inoculum is injected via the intraperitoneal route. Design and Methods: In interest of animal welfare and to reduce the number...
Open access
Research Article10.9734/bjpr/2016/29932
Aims: To perform anti-microbial activity guided isolation and to characterize compound(s) from fruit pulp (extracts) of Azanza garckeana. Place and Duration of Study: Department of chemistry, University of Agriculture, Makurdi, Nigeria, and University of Strathclyde in Scotland,...
Open access
Research Article10.9734/bjpr/2016/30152
Background: Alchornea laxiflora is a medicinal plant with immense health benefits. Aim: To verify the protective effects of methanol extract of Alchornea laxiflora (MEAL) leaf on hepatotoxicity and reproductive toxicity induced by CCl4. Settings and Design: Extraction and adminis...
Open access
Research Article10.9734/bjpr/2016/29807
Aim: To prevent proliferation of mosquito borne diseases, to improve quality of life, mosquito control is essential. Research was aimed to find alternative eco-friendly and bio-degradable strategies in mosquito control at the larvae stage. Hence an attempt was made to study the l...
Open access
Research Article10.9734/bjpr/2016/29878
Several pathogenic bacteria are developing antibiotic resistance. Recovery from multidrug resistant (MDR) infections is a problematic issue and requires a multiple treatment with broad-spectrum antibiotics which are less effective, more toxic and more expensive. Silver nanopartic...
Open access
Research Article10.9734/bjpr/2016/30525
Contemporary civilization is facing more than thousands of disorders accompanied with free radicals. Antioxidants from edible and non-edible mushrooms are gaining importance to fight these disorders. The current investigation was intended to evaluate antioxidant and cytotoxic eff...
Open access
Research Article10.9734/bjpr/2016/30594
Introduction: Recently there has been a great deal of interest in the health benefits of phytochemicals, particularly prenylated and allylated flavonoids. Chalcones (1, 3-diaryl-2-propen-1-ones) and their derivatives are important intermediates of the flavonoid synthetic pathway....
Open access
Research Article10.9734/bjpr/2016/28243
Acacia mearnsii is characterized as a tree with dark green leaves and grow on any types of soil. Its bipinnate leaves with individual leaflets that are used in folk medicine in wound healing, antioxidant, anti-inflammatory and antiviral. Phytochemical tests demonstrated the prese...
Open access
Research Article10.9734/bjpr/2016/30173
This study was designed to determine the acute and subacute toxicity of non-ionic surfactant, sorbitan monostearate (Span 60) vesicles in a Sprague Dawley rat model. The primary aim was to investigate the acute toxicity of Span 60 niosomes after single intraperitoneal (IP) as wel...
Open access
Research Article10.9734/bjpr/2016/30380
Introduction: The rapid increase in the use and consumption of herbal remedies worldwide has been stimulated by several factors, including the notion that most herbal products are safe and effective. Aim: This work was designed to evaluate the acute and subchronic toxicity of ora...
Open access
Research Article10.9734/bjpr/2016/27237
The Mucoadhesive drug delivery system has occupied an important place in the field of pharmaceutical research. Mucoadhesive tablets prolong the residence time of the drug at the site of application and provide extended therapeutic effect. Mucoadhesive tablets have been prepared f...
Open access
Research Article10.9734/bjpr/2016/30629
Nigella sativa is considered as a miracle drug. Although there is a list of diseases which can be treated by it but role of N.s seeds in treatment of diabetes is substantially important. There are multiple classes of antidiabetic agents which ameliorate the hyperglycemia by diffe...
Open access
Research Article10.9734/bjpr/2016/30684
Aims: This study was aimed to evaluate the potential of using Raphia hookeri gum as a binder in tablet formulations. Study Design: Extract of Raphia hookeri gum was investigated as a binding agent in paracetamol tablet formulation in comparison with gelatin BP as standard binder....
Open access
Research Article10.9734/bjpr/2016/28610
Inhibition of angiogenesis is one of the mechanisms of action of anticancer drugs. The current study was designed to probe into anti-angiogenic effect of Mentha longifolia by employing Chorioallantoic membrane assay. White leghorn fertilized eggs were used in the study (n=10). On...
Open access
Research Article10.9734/bjpr/2016/31083
Aims: This paper mentions of the investigation of the enzymes binding to Voglibose and the choice of the enzyme which is suitable for drug enzyme interaction as used in biosensing. Voglibose is an antidiabetic drug which is reactive and hence used in very low concentrations. The...
Open access
Research Article10.9734/bjpr/2016/30369