An Investigation into the Molecular Mechanism of Inverse Relationship between S. Creatinine and HDL-C in CKD

Abstract

An inverse relationship between the raised Serum creatinine (Crn) and High density lipoprotein cholesterol (HDL-C) is well known. A raised S. Creatinine / low estimated glomerular filtration rate (eGFR) is a marker of chronic kidney disease (CKD). Besides, the eGFR, indicates the rate of progression of CKD and helps in the staging of CKD. Any relationship involving the raised creatinine or reduced eGFR necessitates the presence of the CKD in the background. While the CKD itself can cause both high S .Creatinine and low HDL-C, the mechanism of the inverse relationship between the two is not clear. Each of the raised creatinine and low HDL-C, have independent risk factors, but the only common risk factor for both, is the sedentary life style. The role of the sedentary life style in the inverse relationship between the raised Cr and low HDL-C, is examined. A possible molecular mechanism is being suggested, connecting the four variables - the raised Crn , low HDL-C, the CKD and the sedentary life style. To this extent the relevant metabolism of both S creatine and HDL-C, are briefly reviewed, as knowledge of the same is intricate to the better understanding of the molecular mechanism proposed.