Effects of Chlorella Supplementation in the Prevention of Iron Deficiency Anemia: A Review of Clinical and Experimental Studies
Maria Laura da Silva, Elton Santos Guedes de Morais, Newton Antas Pereira, Cíntia Chaves, Pedro Henrique Imazaki, Clarissa Detomi de Albuquerque, Elizabeth Sampaio de Medeiros, Anísio Francisco Soares
Archives of Current Research International · pp. 250–260 · Published 17 Oct 2025
10.9734/acri/2025/v25i101565Abstract
Aims: This review aimed to evaluate the potential of Chlorella supplementation as a natural alternative for the prevention and treatment of iron-deficiency anemia, emphasizing its nutritional profile, bioactive compounds, and effects on hematological parameters. Study Design: Systematic and descriptive-analytical review of clinical and experimental studies. Place and Duration of Study: Studies published between 2014 and 2024, conducted in different regions, were included without geographical restriction. Methodology: A total of 70 scientific articles were initially identified. After applying eligibility criteria and assessing methodological quality, 36 studies were selected for analysis. The review was conducted in PubMed, Web of Science, and Scopus databases using controlled descriptors and Boolean operators, such as ("nutritional profile" OR "nutritional composition") AND ("Chlorella vulgaris" OR "Chlorella spp"); ("Anemia" AND "Chlorella microalgae"); ("Iron Supplementation"); and ("proteins" OR "lipids" OR "carbohydrates" OR "amino acids" OR "antioxidants" OR "bioactive compounds"). Results: Evidence suggests that Chlorella supplementation may improve hematological parameters, particularly hemoglobin levels, due to its high iron bioavailability and additional nutrients such as vitamins, minerals, and antioxidants. Compared with conventional therapies, Chlorella was generally associated with better tolerability and fewer adverse effects, potentially improving adherence. However, the absence of large-scale, long-term trials and limited direct comparisons with pharmaceutical iron restrict the generalization of current findings. Conclusion: Chlorella represents a promising complementary approach for the management of mild to moderate iron-deficiency anemia. Further multicenter and long-term clinical trials are required to confirm its efficacy, safety, and cost-effectiveness, as well as to define its potential role in standard therapeutic protocols.
Cited by 0
No indexed citations yet.
Related research
- Antifungal Activity of Pseudomonas frederiksbergensis CMAA 1323 Isolated from the Antarctic Hair Grass Deschampsia antarctica — shares topic coverage
- Selection of Marine Actinomycetes with Bioactive Potential Isolated from Sediments of Bay of Bengal and Characterization of Promising Isolate, ABT-103 — shares topic coverage
- Phytochemical Analysis and In-vitro Antioxidant Activities of Some Selected Higher Fungi from Oyo State, South West of Nigeria — shares topic coverage
- Bioactive Compounds from Mangosteen Fruit Peels (Garcinia mangostana L.) and Assessment of their Antioxidant Potential — shares topic coverage
- Comparative Phytochemical Profiling and Antimicrobial Efficacy of Ganoderma and Shiitake Mushrooms: A Microbiological Perspective — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
0
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.